Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064804525> ?p ?o ?g. }
- W2064804525 endingPage "349" @default.
- W2064804525 startingPage "330" @default.
- W2064804525 abstract "In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-responsive element-binding protein (CREB) activation suggests that this transcription factor plays a critical role in integrating different inputs and mediating appropriate neuronal responses. The nature of this transcriptional response depends on both the type and strength of the stimulus and the cellular context. CREB-dependent gene expression has been involved in many different aspects of nervous system function, from embryonic development to neuronal survival, and synaptic, structural, and intrinsic plasticity. Here, we first review the different methodological approaches used to genetically manipulate CREB activity and levels in neurons in vivo in the adult brain, including recombinant viral vectors, mouse transgenesis, and gene-targeting techniques. We then discuss the impact of these approaches on our understanding of CREB's roles in neuronal plasticity and memory in rodents. Studies combining these genetic approaches with electrophysiology and behavior provide strong evidence that CREB is critically involved in the regulation of synaptic plasticity, intrinsic excitability, and long-term memory formation. These findings pave the way for the development of novel therapeutic strategies to treat memory disorders." @default.
- W2064804525 created "2016-06-24" @default.
- W2064804525 creator A5016232722 @default.
- W2064804525 creator A5042232111 @default.
- W2064804525 date "2011-09-23" @default.
- W2064804525 modified "2023-09-30" @default.
- W2064804525 title "Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory" @default.
- W2064804525 cites W146042428 @default.
- W2064804525 cites W1507259159 @default.
- W2064804525 cites W1530078590 @default.
- W2064804525 cites W1532762518 @default.
- W2064804525 cites W1542081124 @default.
- W2064804525 cites W1608481794 @default.
- W2064804525 cites W1671833268 @default.
- W2064804525 cites W1867235774 @default.
- W2064804525 cites W1874442292 @default.
- W2064804525 cites W1912689628 @default.
- W2064804525 cites W1928329059 @default.
- W2064804525 cites W1960607431 @default.
- W2064804525 cites W1964374986 @default.
- W2064804525 cites W1965722126 @default.
- W2064804525 cites W1966615413 @default.
- W2064804525 cites W1968661417 @default.
- W2064804525 cites W1968671776 @default.
- W2064804525 cites W1970965220 @default.
- W2064804525 cites W1973141367 @default.
- W2064804525 cites W1976344568 @default.
- W2064804525 cites W1976441097 @default.
- W2064804525 cites W1978438606 @default.
- W2064804525 cites W1982012586 @default.
- W2064804525 cites W1984260356 @default.
- W2064804525 cites W1987030209 @default.
- W2064804525 cites W1988004907 @default.
- W2064804525 cites W1988181440 @default.
- W2064804525 cites W1988256844 @default.
- W2064804525 cites W1989114376 @default.
- W2064804525 cites W1992912736 @default.
- W2064804525 cites W1992949123 @default.
- W2064804525 cites W1994088328 @default.
- W2064804525 cites W1995114419 @default.
- W2064804525 cites W1999782689 @default.
- W2064804525 cites W2002252799 @default.
- W2064804525 cites W2005275397 @default.
- W2064804525 cites W2005583856 @default.
- W2064804525 cites W2006136005 @default.
- W2064804525 cites W2006472411 @default.
- W2064804525 cites W2006777504 @default.
- W2064804525 cites W2006843558 @default.
- W2064804525 cites W2006914006 @default.
- W2064804525 cites W2008037029 @default.
- W2064804525 cites W2009229814 @default.
- W2064804525 cites W2009661936 @default.
- W2064804525 cites W2011029903 @default.
- W2064804525 cites W2011144010 @default.
- W2064804525 cites W2012639972 @default.
- W2064804525 cites W2013336412 @default.
- W2064804525 cites W2013738579 @default.
- W2064804525 cites W2014530155 @default.
- W2064804525 cites W2015839373 @default.
- W2064804525 cites W2016027614 @default.
- W2064804525 cites W2016404201 @default.
- W2064804525 cites W2018128016 @default.
- W2064804525 cites W2018312069 @default.
- W2064804525 cites W2018363412 @default.
- W2064804525 cites W2022713347 @default.
- W2064804525 cites W2022959246 @default.
- W2064804525 cites W2023418630 @default.
- W2064804525 cites W2025176554 @default.
- W2064804525 cites W2025247587 @default.
- W2064804525 cites W2026079063 @default.
- W2064804525 cites W2030575711 @default.
- W2064804525 cites W2030852267 @default.
- W2064804525 cites W2032425419 @default.
- W2064804525 cites W2032878193 @default.
- W2064804525 cites W2034713698 @default.
- W2064804525 cites W2034861130 @default.
- W2064804525 cites W2036396876 @default.
- W2064804525 cites W2036867468 @default.
- W2064804525 cites W2037267899 @default.
- W2064804525 cites W2039017058 @default.
- W2064804525 cites W2044806898 @default.
- W2064804525 cites W2044853135 @default.
- W2064804525 cites W2047148152 @default.
- W2064804525 cites W2047961525 @default.
- W2064804525 cites W2048139752 @default.
- W2064804525 cites W2049134173 @default.
- W2064804525 cites W2049796382 @default.
- W2064804525 cites W2050314347 @default.
- W2064804525 cites W2051945956 @default.
- W2064804525 cites W2053544091 @default.
- W2064804525 cites W2054401541 @default.
- W2064804525 cites W2054943870 @default.
- W2064804525 cites W2057855503 @default.
- W2064804525 cites W2057969497 @default.
- W2064804525 cites W2060246858 @default.
- W2064804525 cites W2060713034 @default.
- W2064804525 cites W2061029688 @default.
- W2064804525 cites W2063065857 @default.