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• W2064832563 abstract "A simple screening technique for measuring protoporphyrin (PROTO) in acidified acetone extracts of capillary blood is described. A statistically significant linear relationship was found between blood lead concentration and loge PROTO concentration. The relationship is sensitive to mild degrees of anemia. The hematocrit may be used to compensate for concurrent anemia when screening for increased lead absorption. When this PROTO assay-microhematocrit procedure was was used prospectively as a screening technique for increased lead absorption, 95 per cent of children with ⪖50 μg Pb were identified, while 90 per cent of those with <30 μg Pb could be classified as normal. The procedure fulfills the need for a simple and reproducible screening test for metabolic injury due to lead. It can be performed quickly in the field with protable equipment so that blood for lead analysis can be obtained simultaneously, when indicated, and preliminary clinical decisions can be facilitated on the spot. Tests for erythrocyte protoporphyrin may be especially useful if repeated at intervals in children who are at greatest risk for clinical plumbism. Preliminary longitudinal studies suggest that serial measurements of erythrocyte protoporphyrin do reflect sustained trends in the assimilation of lead and long-term responses to chelation therapy. A simple screening technique for measuring protoporphyrin (PROTO) in acidified acetone extracts of capillary blood is described. A statistically significant linear relationship was found between blood lead concentration and loge PROTO concentration. The relationship is sensitive to mild degrees of anemia. The hematocrit may be used to compensate for concurrent anemia when screening for increased lead absorption. When this PROTO assay-microhematocrit procedure was was used prospectively as a screening technique for increased lead absorption, 95 per cent of children with ⪖50 μg Pb were identified, while 90 per cent of those with <30 μg Pb could be classified as normal. The procedure fulfills the need for a simple and reproducible screening test for metabolic injury due to lead. It can be performed quickly in the field with protable equipment so that blood for lead analysis can be obtained simultaneously, when indicated, and preliminary clinical decisions can be facilitated on the spot. Tests for erythrocyte protoporphyrin may be especially useful if repeated at intervals in children who are at greatest risk for clinical plumbism. Preliminary longitudinal studies suggest that serial measurements of erythrocyte protoporphyrin do reflect sustained trends in the assimilation of lead and long-term responses to chelation therapy." @default.
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• W2064832563 date "1974-04-01" @default.
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• W2064832563 title "A simple protoporphyrin assay-microhematocrit procedure as a screening technique for increased lead absorption in young children" @default.
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• W2064832563 doi "https://doi.org/10.1016/s0022-3476(74)80666-9" @default.
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