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• W2064868085 abstract "XC6422 is a conserved hypothetical protein from Xanthomonas campestris pathovar campestris (Xcc), a Gram-negative yellow-pigmented pathogenic bacterium that causes black rot, one of the major worldwide diseases of cruciferous crops. The protein consists of 220 amino acids and its structure has been determined to 1.6 A resolution using the multi-wavelength anomalous dispersion (MAD) method. Although it has very low sequence identity to protein sequences in the PDB (less than 20%), the determined structure nevertheless shows that it belongs to the superfamily of serine alpha/beta-hydrolases, with an active site that is fully accessible to solvent owing to the absence of a lid domain. Modelling studies with the serine esterase inhibitor E600 indicate that XC6422 adopts a conserved Ser-His-Asp catalytic triad common to this superfamily and has a preformed oxyanion hole for catalytic activation. These structural features suggest that XC6422 is most likely to be a hydrolase active on a soluble ester or a small lipid. An extra strand preceding the first beta-strand in the canonical alpha/beta-hydrolase fold leads to extensive subunit interactions between XC6422 monomers, which may explain why XC6422 crystals of good diffraction quality can grow to dimensions of up to 1.5 mm in a few days." @default.
• W2064868085 created "2016-06-24" @default.
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• W2064868085 date "2006-05-31" @default.
• W2064868085 modified "2023-10-09" @default.
• W2064868085 title "Structure of XC6422 from<i>Xanthomonas campestris</i>at 1.6 Å resolution: a small serine α/β-hydrolase" @default.
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• W2064868085 doi "https://doi.org/10.1107/s1744309106016265" @default.
• W2064868085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2243109" @default.
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