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• W2064876412 startingPage "748" @default.
• W2064876412 abstract "Glioblastoma multiforme (GBM) is the most common brain tumour and has the worst prognosis. Epidermal growth factor receptor (EGFR) gene amplification, mutation and re-arrangement (all of which enhance tumour growth, survival, progression and resistance to therapy) are frequently observed in primary GBM. The most common EGFR variant in GBM, the EGFRvIII, is characterised by a deletion of 267 amino acids in the extracellular domain, leading to a receptor which is unable to bind ligand yet is constitutively active. Together with its impaired internalisation and degradation, the EGFRvIII enhances the tumourigenic potential of GBM by activating and sustaining mitogenic, anti-apoptotic and pro-invasive signalling pathways. This EGFRvIII-mediated enhanced tumourigenicity combined with the lack of EGFRvIII expression in normal tissue makes it an ideal candidate for targeted therapy. This review summarizes the current knowledge about the role of EGFRvIII in GBM and discusses therapeutic agents targeting EGFRvIII that are being evaluated as treatments for GBM." @default.
• W2064876412 created "2016-06-24" @default.
• W2064876412 creator A5003231470 @default.
• W2064876412 creator A5010378038 @default.
• W2064876412 creator A5054088397 @default.
• W2064876412 date "2009-06-01" @default.
• W2064876412 modified "2023-10-09" @default.
• W2064876412 title "The EGFRvIII variant in glioblastoma multiforme" @default.
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• W2064876412 doi "https://doi.org/10.1016/j.jocn.2008.12.005" @default.
• W2064876412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19324552" @default.
• W2064876412 hasPublicationYear "2009" @default.
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