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• W2064889056 abstract "Article1 May 1963Oral Vitamin B12 without Intrinsic Factor in the Treatment of Pernicious AnemiaS. O. WAIFE, M.D., F.A.C.P., C. J. JANSEN JR., M.D., R. E. CRABTREE, PH.D., E. L. GRINNAN, PH.D., P. J. FOUTS, M.D., F.A.C.P.S. O. WAIFE, M.D., F.A.C.P.Search for more papers by this author, C. J. JANSEN JR., M.D.Search for more papers by this author, R. E. CRABTREE, PH.D.Search for more papers by this author, E. L. GRINNAN, PH.D.Search for more papers by this author, P. J. FOUTS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the discovery of vitamin B12as the essential hematopoietic factor deficient in patients with pernicious anemia in relapse, there have been a number of studies using crystalline cyanocobalamin, without intrinsic factor, in oral therapy. Doses of less than 30 micrograms a day generally have been unsuccessful (1). Suboptimal responses have been reported on doses of up to 100 micrograms a day (1, 2). Better results have followed administration of still larger amounts—as much as 1,000 micrograms a day (3). Other schedules have been used, for example, 1,000 micrograms (1 milligram) once a week (3-7). In Table 1, we have...References1. BRODYESTRENWASSERMAN EASLR: Treatment of pernicious anemia by oral administration of vitamin B12 without added intrinsic factor. New Engl. J. Med. 260: 361, 1959. CrossrefMedlineGoogle Scholar2. CHALMERSSHINTON JNNK: Absorption of orally administered vitamin B12 in pernicious anaemia. Lancet 2: 1298, 1958. CrossrefMedlineGoogle Scholar3. MCINTYREHAHNMASTERSKREVANS PARJMJR: Treatment of pernicious anemia with orally administered cyanocobalamin (vitamin B12). Arch. Intern. Med. 106: 280, 1960. CrossrefGoogle Scholar4. REISNERWEINERSCHITTONEHENCK EHLMTEA: Oral treatment of pernicious anemia with vitamin B12 without intrinsic factor. New Engl. J. Med. 253: 502, 1955. CrossrefMedlineGoogle Scholar5. HEMSTEDMILLS EHJ: Vitamin B12 in pernicious anaemia; intramuscular or oral? Lancet 2: 1302, 1958. CrossrefMedlineGoogle Scholar6. CONLEYKREVANS CLJR: New developments in the diagnosis and treatment of pernicious anemia. Ann. Intern. Med. 43: 758, 1955. LinkGoogle Scholar7. UNGLAUBGOLDSMITH WGGA: Oral vitamin B12 in the treatment of macrocytic anemias. Southern Med. J. 48: 261, 1955. CrossrefMedlineGoogle Scholar8. GLASSLEESKEGGSSTANLEY GBDHHRJL: Long-acting effects of hydroxocobalamin on B12 deficiency in man. Fed. Proc. 21: 471, 1962 (abstracts). Google Scholar9. KACZKAWOLFKUEHLFOLKERS EADEFAK: Vitamin B12. XVI. Modifications of cyano-cobalamin. J. Amer. Chem. Soc. 73: 3569, 1951. CrossrefGoogle Scholar10. KACZKAWOLFFOLKERS EDEK: Vitamin B12. V. Identification of crystalline vitamin B12. J. Amer. Chem. Soc. 71: 1514, 1949. CrossrefMedlineGoogle Scholar11. SMITHMARTINGREGORYSHAW ELJLRJWH: Standardisation of hydroxocobalamin. Analyst 87: 183, 1962. CrossrefGoogle Scholar12. DOSCHERHOLMENHAGEN APS: A dual mechanism of vitamin B12 plasma absorption. J. Clin. Invest. 36: 1551, 1957. CrossrefMedlineGoogle Scholar13. UNGLAUBMILLERGOLDSMITH WGONGA: Saturation studies with vitamin B12 in human subjects. Fed. Proc. 15: 374, 1956. Google Scholar14. BERLINBERLINBRANTESJÖBERG HRGS: The absorption of IF-bound and free B12 in various clinical conditions, in Vitamin B12 und Intrinsic Factor: Europäisches Symposion, Hamburg 1961, Ferdinand Enke, Stuttgart, 1962, p. 485. Google Scholar15. CALLENDEREVANS STJR: The urinary excretion of labelled vitamin B12. Clin. Sci. 14: 295, 1955. MedlineGoogle Scholar16. DARBYJONESCLARKMCGANITYDE OLIVEIRAPEREZKEVANYLE BROCQUY WJESLWJJDCJJ: The development of vitamin B12 deficiency by untreated patients with pernicious anemia. Amer. J. Clin. Nutr. 6: 513, 1958. CrossrefMedlineGoogle Scholar17. BAKERMOLLIN SJDL: The relationship between intrinsic factor and the intestinal absorption of vitamin B12. Brit. J. Haemat. 1: 46, 1955. CrossrefMedlineGoogle Scholar18. BESTWHITEROBBINSLANDMANNSTEELMAN WRWFKCWASL: Studies on urinary excretion of vitamin B12Co60 in pernicious anemia for determining effective dosage of intrinsic factor concentrates. Blood 11: 338, 1956. CrossrefMedlineGoogle Scholar19. HEINRICH HC: Biological half-life and turnover rate of vitamin B12 in humans. Z. Naturforsch. 16B: 407, 1961. CrossrefGoogle Scholar20. GRÄSBECK R: Calculations on vitamin B12 turnover in man. Scand. J. Clin. Lab. Invest. 11: 250, 1959. MedlineGoogle Scholar21. ADAMS JF: Considerations governing the maintenance treatment of patients with pernicious anaemia, in Vitamin B12 und Intrinsic Factor: Europäisches Symposion, Hamburg 1961, Ferdinand Enke, Stuttgart, 1962, p. 673. Google Scholar22. KILLANDERSCHILLING ARF: Studies on hydroxocobalamin. I. Excretion and retention of massive doses in control subjects. J. Lab. Clin. Med. 57: 553, 1961. MedlineGoogle Scholar23. GLASSSKEGGSLEEJONESHARDY GBHRDHELWW: Applicability of hydroxocobalamin as a long-acting vitamin B12 in man, in Vitamin B12 und Intrinsic Factor: Europäisches Symposion, Hamburg 1961, Ferdinand Enke, Stuttgart, 1962, p. 673. Google Scholar24. HEINRICHGABBE HCEE: Internal retention and excretion of aquocobamide, a depot-form of natural vitamin B12 suitable for therapy. Klin. Wschr. 39: 689, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. O. WAIFE, M.D., F.A.C.P.; C. J. JANSENJR., M.D.; R. E. CRABTREE, PH.D.; E. L. GRINNAN, PH.D.; P. J. FOUTS, M.D., F.A.C.P.Affiliations: Indianapolis, IndianaFrom the Lilly Research Laboratories and the Lilly Laboratory for Clinical Research, Indianapolis, Indiana.Presented at the IX Congress of the International Society of Hematology, Mexico D. F., September, 1962.Requests for reprints should be addressed to S. O. Waife, M.D., Medical Editorial Department, Lilly Research Laboratories, Indianapolis 6, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 DeficiencyVitamin B12 deficiency in patients undergoing bariatric surgery: Preventive strategies and key recommendationsVitamin B 12ANEMIAS AND CYTOPENIASOral cobalamin remains medicine's best kept secretOral vitamin B12therapy in the primary care setting: a qualitative and quantitative study of patient perspectivesOral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiencyOral vitamin b12 therapy in vitamin b12 deficiencyTreatment of Vitamin B 12 –Deficiency Anemia: Oral versus Parenteral TherapyEffective Treatment of Cobalamin Deficiency With Oral CobalaminEffective Treatment of Cobalamin Deficiency With Oral CobalaminNasal absorption of hydroxocobalamin in healthy elderly adultsVitamin B-12 deficiency in the elderly: current dilemmasNORMALIZATION OF LOW VITAMIN B 12 SERUM LEVELS IN OLDER PEOPLE BY ORAL TREATMENTScreening the Older Population for Cobalamin (Vitamin B 12 ) DeficiencyPernicious Anemia RevisitedIron Deficiency and Megaloblastic AnemiasCobalamin and unsaturated transcobalamin values in pernicious anaemia: Relation to treatmentVitamin B12 Deficiency in Cystic FibrosisCobalamin Forms in Plasma and Tissue during Treatment of Vitamin B12 DeficiencyCHAPTER 11: Summary to Section IIVitamin-responsive genetic diseaseNormal and Promoted GI Absorption of Water-Soluble Substances II: Absorption of Vitamin B12 from Ligated Stomach and Intact Intestine of the RatDiscussion of Thedering's PaperORAL TREATMENT OF PERNICIOUS ANEMIA WITH HIGH DOSES OF VITAMIN B12 WITHOUT INTRINSIC FACTORPharmaceutical Sciences—1963. Part IIAnemia and heart diseaseStudies of the small-intestinal bacterial flora and of intestinal absorption in pernicious anemia 1 May 1963Volume 58, Issue 5Page: 810-817KeywordsAnemiaClinical laboratoriesCyanocobalaminExcretionHematology and oncologyPernicious anemiaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ..." @default.
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