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- W2064897388 abstract "Abstract Two protein bands, resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, account for most of the cytochrome P -450 in Drosophila melanogaster . P -450-A is ubiquitous among strains tested; whereas P -450-B is unique to certain strains. Dimethylnitrosamine demethylase activity is associated with P -450-B. Biochemical and genetic analyses showed that genes located on chromosome II were required for P -450-B expression. These genes were mapped within an interval that includes a major insecticide-resistance locus. Regulatory loci on chromosome III were required for maximum expression of P -450-B. One of these regulatory loci was mapped at another major resistance locus on chromosome III. There was a good correlation between P -450-B expression and resistance to phenylurea among the different strains tested. These results indicate that Drosophila can be a useful model to study the molecular mechanisms of insecticide resistance." @default.
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- W2064897388 title "Regulation of insecticide resistance-related cytochrome P-450 expression in Drosophila melanogaster" @default.
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