FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064910801> ?p ?o ?g. }

• W2064910801 endingPage "1262" @default.
• W2064910801 startingPage "1253" @default.
• W2064910801 abstract "Study Objective. To evaluate the single- and multiple-dose pharmacokinetics of an oral extended-release formulation of guanfacine in children and adolescents with a diagnosis of attention-deficit–hyperactivity disorder (ADHD). Design. Phase I-II, open-label, dose-escalation study. Setting. Clinical study center. Patients. Fourteen children (aged 6–12 yrs) and 14 adolescents (aged 13–17 yrs) with ADHD. Intervention. All patients received guanfacine as a single 2-mg dose on day 1. They received a daily dose of 2 mg on days 9–15, 3 mg on days 16–22, and 4 mg on days 23–29. Measurements and Main Results. Blood samples, vital signs, and electrocardiograms (ECGs) were obtained before dosing on day 1 and at intervals over 24 hours, with repeat measurements on days 14 and 28. Guanfacine demonstrated linear pharmacokinetics. Mean plasma concentrations, peak exposure (Cmax), and total or 24-hour exposure (area under the concentration-time curve [AUC]0–∞ or AUC0–24, respectively) were as follows in children and adolescents, respectively: after a single 2-mg dose, AUC0–∞ was 65.2 ± 23.9 ng•hour/ml and 47.3 ± 13.7 ng•hour/ml, and Cmax was 2.55 ± 1.03 ng/ml and 1.69 ± 0.43 ng/ml; after multiple 2-mg doses, AUC0–24 was 70.0 ± 28.3 ng•hour/ml and 48.2 ± 16.1 ng•hour/ml, and Cmax was 4.39 ± 1.66 ng/ml and 2.86 ± 0.77 ng/ml; and after multiple 4-mg doses, AUC0–24 was 162 ± 116 ng•hour/ml and 117 ± 28.4 ng•hour/ml, and Cmax was 10.1 ± 7.09 ng/ml and 7.01 ± 1.53 ng/ml. After a single 2-mg dose, half-life was 14.4 ± 2.39 hours in children and 17.9 ± 5.77 hours in adolescents. The most frequent treatment-emergent adverse events were somnolence, insomnia, headache, blurred vision, and altered mood. Most were mild to moderate in severity, with the highest frequency associated with the 4-mg doses. Blood pressure, pulse, and ECG readings were all within normal limits. Conclusion. Guanfacine extended-release formulation demonstrated linear pharmacokinetics. Plasma concentrations and concentration-related pharmacokinetic parameters were higher in children than in adolescents. These differences are likely due to heavier body weights in adolescents and young male subjects. No serious adverse events were reported." @default.
• W2064910801 created "2016-06-24" @default.
• W2064910801 creator A5020484375 @default.
• W2064910801 creator A5027354439 @default.
• W2064910801 creator A5067786420 @default.
• W2064910801 creator A5075206586 @default.
• W2064910801 creator A5076784753 @default.
• W2064910801 date "2007-09-01" @default.
• W2064910801 modified "2023-09-27" @default.
• W2064910801 title "Pharmacokinetics of a Guanfacine Extended-Release Formulation in Children and Adolescents with Attention-Deficit–Hyperactivity Disorder" @default.
• W2064910801 cites W1501686051 @default.
• W2064910801 cites W1965392517 @default.
• W2064910801 cites W1968161022 @default.
• W2064910801 cites W1972639908 @default.
• W2064910801 cites W1982166376 @default.
• W2064910801 cites W2000247756 @default.
• W2064910801 cites W2018897037 @default.
• W2064910801 cites W2032807853 @default.
• W2064910801 cites W2033304004 @default.
• W2064910801 cites W2039755273 @default.
• W2064910801 cites W2042348492 @default.
• W2064910801 cites W2053758131 @default.
• W2064910801 cites W2122625420 @default.
• W2064910801 cites W2147123664 @default.
• W2064910801 cites W2164549762 @default.
• W2064910801 doi "https://doi.org/10.1592/phco.27.9.1253" @default.
• W2064910801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17723079" @default.
• W2064910801 hasPublicationYear "2007" @default.
• W2064910801 type Work @default.
• W2064910801 sameAs 2064910801 @default.
• W2064910801 citedByCount "46" @default.
• W2064910801 countsByYear W20649108012012 @default.
• W2064910801 countsByYear W20649108012013 @default.
• W2064910801 countsByYear W20649108012014 @default.
• W2064910801 countsByYear W20649108012015 @default.
• W2064910801 countsByYear W20649108012016 @default.
• W2064910801 countsByYear W20649108012017 @default.
• W2064910801 countsByYear W20649108012018 @default.
• W2064910801 countsByYear W20649108012019 @default.
• W2064910801 countsByYear W20649108012020 @default.
• W2064910801 countsByYear W20649108012021 @default.
• W2064910801 countsByYear W20649108012022 @default.
• W2064910801 countsByYear W20649108012023 @default.
• W2064910801 crossrefType "journal-article" @default.
• W2064910801 hasAuthorship W2064910801A5020484375 @default.
• W2064910801 hasAuthorship W2064910801A5027354439 @default.
• W2064910801 hasAuthorship W2064910801A5067786420 @default.
• W2064910801 hasAuthorship W2064910801A5075206586 @default.
• W2064910801 hasAuthorship W2064910801A5076784753 @default.
• W2064910801 hasConcept C112705442 @default.
• W2064910801 hasConcept C118552586 @default.
• W2064910801 hasConcept C187212893 @default.
• W2064910801 hasConcept C22979827 @default.
• W2064910801 hasConcept C2777288759 @default.
• W2064910801 hasConcept C2778399450 @default.
• W2064910801 hasConcept C2780783007 @default.
• W2064910801 hasConcept C2780815205 @default.
• W2064910801 hasConcept C42219234 @default.
• W2064910801 hasConcept C71924100 @default.
• W2064910801 hasConcept C98274493 @default.
• W2064910801 hasConceptScore W2064910801C112705442 @default.
• W2064910801 hasConceptScore W2064910801C118552586 @default.
• W2064910801 hasConceptScore W2064910801C187212893 @default.
• W2064910801 hasConceptScore W2064910801C22979827 @default.
• W2064910801 hasConceptScore W2064910801C2777288759 @default.
• W2064910801 hasConceptScore W2064910801C2778399450 @default.
• W2064910801 hasConceptScore W2064910801C2780783007 @default.
• W2064910801 hasConceptScore W2064910801C2780815205 @default.
• W2064910801 hasConceptScore W2064910801C42219234 @default.
• W2064910801 hasConceptScore W2064910801C71924100 @default.
• W2064910801 hasConceptScore W2064910801C98274493 @default.
• W2064910801 hasIssue "9" @default.
• W2064910801 hasLocation W20649108011 @default.
• W2064910801 hasLocation W20649108012 @default.
• W2064910801 hasOpenAccess W2064910801 @default.
• W2064910801 hasPrimaryLocation W20649108011 @default.
• W2064910801 hasRelatedWork W2002127959 @default.
• W2064910801 hasRelatedWork W2004706469 @default.
• W2064910801 hasRelatedWork W2064910801 @default.
• W2064910801 hasRelatedWork W2080969318 @default.
• W2064910801 hasRelatedWork W2379280247 @default.
• W2064910801 hasRelatedWork W2604417740 @default.
• W2064910801 hasRelatedWork W2604484584 @default.
• W2064910801 hasRelatedWork W2899072855 @default.
• W2064910801 hasRelatedWork W2972898444 @default.
• W2064910801 hasRelatedWork W3151787567 @default.
• W2064910801 hasVolume "27" @default.
• W2064910801 isParatext "false" @default.
• W2064910801 isRetracted "false" @default.
• W2064910801 magId "2064910801" @default.
• W2064910801 workType "article" @default.