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- W2064913418 abstract "Aldosterone synthase (CYP11B2) T-344C gene polymorphism was found to be correlated with atrial fibrillation (AF) risk. However, the results of individual studies remain conflicting.A meta-analysis including 2,758 subjects from six individual studies was performed to explore the correlation between CYP11B2 T-344C gene polymorphisms and AF. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by the fixed- or random-effects model.A significant relationship between CYP11B2 T-344C gene polymorphism and AF was found under allelic (OR: 1.26, 95% CI: 1.11-1.42, P = 0.0002), recessive (OR: 1.99, 95% CI: 1.26-3.14, P = 0.003), dominant (OR: 0.903, 95% CI: 0.820-0.994, P = 0.036), homozygous (OR: 1.356, 95% CI: 1.130-1.628, P = 0.001), and additive (OR: 1.153, 95% CI: 1.070-1.243, P = 1.0×10(-10)) genetic models. No significant association between CYP11B2 T-344C gene polymorphism and AF was found under the heterozygous genetic model (OR: 1.040, 95% CI: 0.956-1.131, P = 0.361).A significant association was found between CYP11B2 T-344C gene polymorphism and AF risk. Individuals with the C allele of CYP11B2 T-344C gene polymorphism have higher risk for AF." @default.
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- W2064913418 date "2012-11-28" @default.
- W2064913418 modified "2023-10-17" @default.
- W2064913418 title "CYP11B2 T-344C Gene Polymorphism and Atrial Fibrillation: A Meta-Analysis of 2,758 Subjects" @default.
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- W2064913418 doi "https://doi.org/10.1371/journal.pone.0050910" @default.
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