FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064914642> ?p ?o ?g. }

• W2064914642 endingPage "1327" @default.
• W2064914642 startingPage "1321" @default.
• W2064914642 abstract "1 The effects of ω-conotoxin GVIA (ω-CgTX) and tetrodotoxin (TTX) on vasoconstrictions induced by acetylcholine (ACh) and nicotine were investigated and compared with those induced by periarterial electrical stimulation in the isolated and perfused canine splenic arteries. 2 ACh and nicotine at doses of 0.01 to 1 μmol constricted the splenic artery, dose-dependently. ACh induced consistent responses, but the vasoconstrictor responses to nicotine became significantly smaller with repeated administration of nicotine. 3 Periarterial electrical stimulation produced a vasoconstriction that was abolished by either TTX (30 nmol) or ω-CgTX (3 nmol), but the vasoconstrictor response to nicotine was not significantly affected by the same doses of TTX and ω-CgTX. Inhibitions by TTX and ω-CgTX of ACh-induced vasoconstrictions were small but statistically significant, showing that the percentage inhibition was less than 15%. TTX and ω-CgTX did not affect the vasoconstrictor responses to exogenous noradrenaline (NA). 4 ACh did not produce any vasoconstriction in the preparations treated either with α-adrenoceptor antagonists (10 μm bunazosin and 10 μm midaglizole) or with 30 μm guanethidine. NA-induced responses were abolished by α-adrenoceptor antagonists, but not affected by guanethidine treatment. 5 Vascular responses to ACh were completely inhibited by 1 μmol hexamethonium. In the preparations treated with 100 nmol nicotine, ACh did not produce any vasoconstriction. However, the NA-induced vasoconstriction was affected by neither hexamethonium nor nicotine treatment. 6 Atropine (1 μm) significantly inhibited but did not abolish the vasoconstrictor responses to ACh. The vascular responses to nicotine and NA were also significantly inhibited by atropine treatment. 7 These results indicate that (1) ACh constricts the splenic artery through the activation of presynaptic nicotinic receptors present on the sympathetic nerves; (2) differential effects of TTX and ω-CgTX on the vascular responses to ACh and nicotine, and to electrical stimulation suggest that the receptor-operated ion channels are mainly responsible for NA release induced by nicotinic receptor stimulation, but N-type VOCCs are responsible for that by electrical stimulation; (3) atropine may have an inhibitory action on nicotine-related responses, in addition to its inhibitory action on NA." @default.
• W2064914642 created "2016-06-24" @default.
• W2064914642 creator A5016706916 @default.
• W2064914642 creator A5042316580 @default.
• W2064914642 creator A5087747659 @default.
• W2064914642 date "1994-04-01" @default.
• W2064914642 modified "2023-09-27" @default.
• W2064914642 title "Differential effects of ω-conotoxin GVIA and tetrodotoxin on vasoconstrictions evoked by electrical stimulation and nicotinic receptor stimulation in canine isolated, perfused splenic arteries" @default.
• W2064914642 cites W1617914701 @default.
• W2064914642 cites W1835817208 @default.
• W2064914642 cites W1854209539 @default.
• W2064914642 cites W1922802412 @default.
• W2064914642 cites W1966453361 @default.
• W2064914642 cites W1969754781 @default.
• W2064914642 cites W1971845958 @default.
• W2064914642 cites W1977446753 @default.
• W2064914642 cites W1997984901 @default.
• W2064914642 cites W2003661602 @default.
• W2064914642 cites W2003947734 @default.
• W2064914642 cites W2013164869 @default.
• W2064914642 cites W2015996189 @default.
• W2064914642 cites W2032254075 @default.
• W2064914642 cites W2033558463 @default.
• W2064914642 cites W2035428388 @default.
• W2064914642 cites W2037349520 @default.
• W2064914642 cites W2038542572 @default.
• W2064914642 cites W2054262206 @default.
• W2064914642 cites W2060533392 @default.
• W2064914642 cites W2060854009 @default.
• W2064914642 cites W2061056399 @default.
• W2064914642 cites W2062042414 @default.
• W2064914642 cites W2064212747 @default.
• W2064914642 cites W2067243679 @default.
• W2064914642 cites W2072128683 @default.
• W2064914642 cites W2072991541 @default.
• W2064914642 cites W2081317127 @default.
• W2064914642 cites W2091951114 @default.
• W2064914642 cites W2092223252 @default.
• W2064914642 cites W2095297193 @default.
• W2064914642 cites W2117594247 @default.
• W2064914642 cites W2123009781 @default.
• W2064914642 cites W2123917020 @default.
• W2064914642 cites W2141226958 @default.
• W2064914642 cites W2255987516 @default.
• W2064914642 cites W2279191656 @default.
• W2064914642 cites W2294091843 @default.
• W2064914642 cites W2306240380 @default.
• W2064914642 cites W2442065273 @default.
• W2064914642 cites W4241685556 @default.
• W2064914642 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14889.x" @default.
• W2064914642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1910132" @default.
• W2064914642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7913375" @default.
• W2064914642 hasPublicationYear "1994" @default.
• W2064914642 type Work @default.
• W2064914642 sameAs 2064914642 @default.
• W2064914642 citedByCount "22" @default.
• W2064914642 crossrefType "journal-article" @default.
• W2064914642 hasAuthorship W2064914642A5016706916 @default.
• W2064914642 hasAuthorship W2064914642A5042316580 @default.
• W2064914642 hasAuthorship W2064914642A5087747659 @default.
• W2064914642 hasBestOaLocation W20649146422 @default.
• W2064914642 hasConcept C126322002 @default.
• W2064914642 hasConcept C134018914 @default.
• W2064914642 hasConcept C170493617 @default.
• W2064914642 hasConcept C185592680 @default.
• W2064914642 hasConcept C188987157 @default.
• W2064914642 hasConcept C24998067 @default.
• W2064914642 hasConcept C2775859210 @default.
• W2064914642 hasConcept C2775893369 @default.
• W2064914642 hasConcept C2775910092 @default.
• W2064914642 hasConcept C2776232365 @default.
• W2064914642 hasConcept C2776741303 @default.
• W2064914642 hasConcept C2779547902 @default.
• W2064914642 hasConcept C2779961880 @default.
• W2064914642 hasConcept C42219234 @default.
• W2064914642 hasConcept C71924100 @default.
• W2064914642 hasConcept C98274493 @default.
• W2064914642 hasConceptScore W2064914642C126322002 @default.
• W2064914642 hasConceptScore W2064914642C134018914 @default.
• W2064914642 hasConceptScore W2064914642C170493617 @default.
• W2064914642 hasConceptScore W2064914642C185592680 @default.
• W2064914642 hasConceptScore W2064914642C188987157 @default.
• W2064914642 hasConceptScore W2064914642C24998067 @default.
• W2064914642 hasConceptScore W2064914642C2775859210 @default.
• W2064914642 hasConceptScore W2064914642C2775893369 @default.
• W2064914642 hasConceptScore W2064914642C2775910092 @default.
• W2064914642 hasConceptScore W2064914642C2776232365 @default.
• W2064914642 hasConceptScore W2064914642C2776741303 @default.
• W2064914642 hasConceptScore W2064914642C2779547902 @default.
• W2064914642 hasConceptScore W2064914642C2779961880 @default.
• W2064914642 hasConceptScore W2064914642C42219234 @default.
• W2064914642 hasConceptScore W2064914642C71924100 @default.
• W2064914642 hasConceptScore W2064914642C98274493 @default.
• W2064914642 hasIssue "4" @default.
• W2064914642 hasLocation W20649146421 @default.
• W2064914642 hasLocation W20649146422 @default.
• W2064914642 hasLocation W20649146423 @default.
• W2064914642 hasLocation W20649146424 @default.

• next