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- W2064921823 abstract "Epithelial-to-mesenchymal transition (EMT) is a reversible process by which cancer cells can switch from a sessile epithelial phenotype to an invasive mesenchymal state. EMT enables tumor cells to become invasive, intravasate, survive in the circulation, extravasate, and colonize distant sites. Paracrine heterotypic stroma-derived signals as well as paracrine homotypic or autocrine signals can mediate oncogenic EMT and contribute to the acquisition of stem/progenitor cell properties, expansion of cancer stem cells, development of therapy resistance, and often lethal metastatic disease. EMT is regulated by a variety of stimuli that trigger specific intracellular signalling pathways. Altered microRNA (miR) expression and perturbed signalling pathways have been associated with epithelial plasticity, including oncogenic EMT. In this review we analyse and describe the interaction between experimentally validated miRs and their target genes in TGF- β , Notch, and Wnt signalling pathways. Interestingly, in this process, we identified a “signature” of 30 experimentally validated miRs and a cluster of validated target genes that seem to mediate the cross talk between TGF- β , Notch, and Wnt signalling networks during EMT and reinforce their connection to the regulation of epithelial plasticity in health and disease." @default.
- W2064921823 created "2016-06-24" @default.
- W2064921823 creator A5000461674 @default.
- W2064921823 creator A5020642638 @default.
- W2064921823 creator A5032290331 @default.
- W2064921823 creator A5083709043 @default.
- W2064921823 date "2015-01-01" @default.
- W2064921823 modified "2023-09-24" @default.
- W2064921823 title "Epithelial Plasticity in Cancer: Unmasking a MicroRNA Network for TGF-<i>β</i>-, Notch-, and Wnt-Mediated EMT" @default.
- W2064921823 cites W1525473722 @default.
- W2064921823 cites W1545414527 @default.
- W2064921823 cites W1689652926 @default.
- W2064921823 cites W1804903768 @default.
- W2064921823 cites W1894832831 @default.
- W2064921823 cites W1955882699 @default.
- W2064921823 cites W1963966397 @default.
- W2064921823 cites W1965371218 @default.
- W2064921823 cites W1966063731 @default.
- W2064921823 cites W1969132788 @default.
- W2064921823 cites W1974804765 @default.
- W2064921823 cites W1976561610 @default.
- W2064921823 cites W1978337436 @default.
- W2064921823 cites W1978944350 @default.
- W2064921823 cites W1983991097 @default.
- W2064921823 cites W1984647773 @default.
- W2064921823 cites W1985414680 @default.
- W2064921823 cites W1988163167 @default.
- W2064921823 cites W1990402395 @default.
- W2064921823 cites W1993579134 @default.
- W2064921823 cites W1995082021 @default.
- W2064921823 cites W1997370405 @default.
- W2064921823 cites W1998190707 @default.
- W2064921823 cites W2002404925 @default.
- W2064921823 cites W2005102765 @default.
- W2064921823 cites W2005918516 @default.
- W2064921823 cites W2008837855 @default.
- W2064921823 cites W2009993892 @default.
- W2064921823 cites W2016848669 @default.
- W2064921823 cites W2017729871 @default.
- W2064921823 cites W2025549697 @default.
- W2064921823 cites W2029736267 @default.
- W2064921823 cites W2033529039 @default.
- W2064921823 cites W2033660315 @default.
- W2064921823 cites W2039057576 @default.
- W2064921823 cites W2040108549 @default.
- W2064921823 cites W2047496561 @default.
- W2064921823 cites W2047992261 @default.
- W2064921823 cites W2051126469 @default.
- W2064921823 cites W2052096221 @default.
- W2064921823 cites W2052917322 @default.
- W2064921823 cites W2055650359 @default.
- W2064921823 cites W2056302937 @default.
- W2064921823 cites W2057505281 @default.
- W2064921823 cites W2058301022 @default.
- W2064921823 cites W2059073003 @default.
- W2064921823 cites W2065566217 @default.
- W2064921823 cites W2065679428 @default.
- W2064921823 cites W2065914207 @default.
- W2064921823 cites W2067896088 @default.
- W2064921823 cites W2070544692 @default.
- W2064921823 cites W2070840393 @default.
- W2064921823 cites W2074664629 @default.
- W2064921823 cites W2075692189 @default.
- W2064921823 cites W2076060004 @default.
- W2064921823 cites W2079113237 @default.
- W2064921823 cites W2080084006 @default.
- W2064921823 cites W2080229987 @default.
- W2064921823 cites W2081113032 @default.
- W2064921823 cites W2083158631 @default.
- W2064921823 cites W2083832224 @default.
- W2064921823 cites W2085543001 @default.
- W2064921823 cites W2092696994 @default.
- W2064921823 cites W2093762155 @default.
- W2064921823 cites W2099277978 @default.
- W2064921823 cites W2099692224 @default.
- W2064921823 cites W2103612496 @default.
- W2064921823 cites W2107261560 @default.
- W2064921823 cites W2110053610 @default.
- W2064921823 cites W2112195516 @default.
- W2064921823 cites W2116201042 @default.
- W2064921823 cites W2118650242 @default.
- W2064921823 cites W2123639306 @default.
- W2064921823 cites W2131400752 @default.
- W2064921823 cites W2131591844 @default.
- W2064921823 cites W2140551998 @default.
- W2064921823 cites W2144971212 @default.
- W2064921823 cites W2145312783 @default.
- W2064921823 cites W2148294117 @default.
- W2064921823 cites W2149914697 @default.
- W2064921823 cites W2150813478 @default.
- W2064921823 cites W2155441355 @default.
- W2064921823 cites W2159482845 @default.
- W2064921823 cites W2167808312 @default.
- W2064921823 cites W2170709726 @default.
- W2064921823 cites W2349550891 @default.
- W2064921823 cites W2614533380 @default.
- W2064921823 cites W2910065277 @default.
- W2064921823 cites W4294216483 @default.