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- W2064935416 abstract "BPs can be grouped into two general classes according to their chemical structure and the molecular mechanism by which they inhibit osteoclast-mediated bone resorption. The simple BPs can be metabolically incorporated into non-hydrolysable analogues of ATP that accumulate intracellularly in osteoclasts, causing osteoclast cell death by apoptosis. By contrast, the more potent N-BPs inhibit FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids that are required for the prenylation of small GTPase signalling proteins necessary for osteoclast function. Inhibition of FPP synthase in cells other than osteoclasts also appears to account for the adverse effects of N-BPs in vivo (including the acute phase reaction) and for the anti-tumour effects of N-BPs in vitro." @default.
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- W2064935416 date "1999-05-01" @default.
- W2064935416 modified "2023-10-18" @default.
- W2064935416 title "Molecular mechanisms of action of bisphosphonates" @default.
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- W2064935416 doi "https://doi.org/10.1016/s8756-3282(99)00070-8" @default.
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