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• W2064941738 startingPage "1305" @default.
• W2064941738 abstract "MicroRNAs (miRNAs) are important regulators of mouse brain development. However, their precise roles in this context remain to be elucidated. Through screening of expression profiles from a miRNA microarray and experimental analysis, we show here that miR-15b controls several aspects of cortical neurogenesis. miR-15b inhibits cortical neural progenitor cell (NPC) proliferation and promotes cell-cycle exit and neuronal differentiation. Additionally, miR-15b expression decreases the number of apical progenitors and increases basal progenitors in the VZ/SVZ. We also show that miR-15b binds to the 3' UTR of TET3, which plays crucial roles during embryonic development by enhancing DNA demethylation. TET3 promotes cyclin D1 expression, and miR-15b reduces TET3 expression and 5hmC levels. Notably, TET3 expression rescues miR-15b-induced impaired NPC proliferation and increased cell-cycle exit in vivo. Our results not only reveal a link between miRNAs, TET, and DNA demethylation but also demonstrate critical roles for miR-15b and TET3 in maintaining the NPC pool during early neocortical development." @default.
• W2064941738 created "2016-06-24" @default.
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• W2064941738 date "2014-10-24" @default.
• W2064941738 modified "2023-10-16" @default.
• W2064941738 title "Micro <scp>RNA</scp> ‐15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing <scp>TET</scp> 3 during early neocortical development" @default.
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• W2064941738 doi "https://doi.org/10.15252/embr.201438923" @default.
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