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- W2064963996 abstract "Abstract Introduction The cochlear nucleus (CN) is vulnerable to physio-pathological alterations with age that may contribute to varied degree of hearing impairment. It was planned to study the age changes in the three-dimensional (3-D) structure of human CN. Methods Forty-one human brainstems were collected (birth − 90 years) from the mortuary of the All India Institute of Medical Sciences (AIIMS), New Delhi, with ethical committee permission. Tissues were fixed in 4% paraformaldehyde (pH 7.4), cryosectioned (40 μm) serially and stained with cresyl violet. A 3-D reconstruction model of the adult human CN was made using the 3-D Solid body tracing probe of the Stereo Investigator software (MBF Biosciences, VT, USA). Results The CN appeared as a thin, crescent-shaped protuberance along the floor and lateral recess of the 4th ventricle in relation with inferior and middle cerebellar peduncle at the level of the pontomedullary junction. The rostral tip was observed deep in the middle cerebellar peduncle and the dorsal subdivision, within the wall of lateral recess of the 4th ventricle. Microscopically, different types of neurons were observed in all the ages studied and no change in the distribution was noted. The volume of the CN did not change with ageing. Discussion The 3-D model of the CN can be used as a landmark for safe surgical route to access the intraventricular surface of the 4th ventricle and to engineer brainstem implants." @default.
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- W2064963996 date "2014-06-01" @default.
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- W2064963996 title "Age associated changes in the human cochlear nucleus – A three-dimensional modelling and its potential application for brainstem implants" @default.
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- W2064963996 doi "https://doi.org/10.1016/j.jasi.2014.04.005" @default.
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