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- W2064965963 abstract "SUMMARY A mouse genomic segment containing three new members of the murine interferon alpha (MuIFN-α) gene family was isolated from a fibroblastic cosmid library. A 4 kb EcoRI fragment contained a new MuIFN-α gene named MuIFN-α8. The nucleotide sequence of the coding and flanking regions of this gene showed a high level of homology to those of known members of the MuIFN-α family. Transient expression of the MuIFN-α8 gene in COS cells and oocyte translation of in vitro transcripts both led to a biologically active protein. The antiviral activity was neutralized by monoclonal and polyclonal MuIFN-α antibodies. Although the 5′ flanking sequence shows features characteristic of an IFN regulatory region, the MuIFN-α8 gene is not expressed in murine fibroblasts treated with Newcastle disease virus or poly(I)·poly(C)." @default.
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- W2064965963 date "1989-06-01" @default.
- W2064965963 modified "2023-09-25" @default.
- W2064965963 title "Isolation and Characterization of a Functional Murine Interferon Alpha Gene which Is Not Expressed in Fibroblasts upon Virus Induction" @default.
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- W2064965963 doi "https://doi.org/10.1099/0022-1317-70-6-1381" @default.
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