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- W2064967874 abstract "Previous research supports the activational role of central cholinergic mechanisms in rodent female sexual behavior. This experiment examined if similar central cholinergic mechanisms facilitate female rhesus monkey (Macaca mulatta) sexual behavior. Eight ovariectomized female rhesus monkeys received daily estradiol benzoate priming (5 μg/kg, SC). After 13–16 days of estrogen priming, animals were injected intravenously with either the cholinergic antagonist, scopolamine (0.70 mg/kg), or saline vehicle (1 ml/kg). Results indicate that the female proceptive behaviors of noncontact presentations significantly decreased 15–45 min after scopolamine injection. Scopolamine inhibition was sustained up to 75 min only after 15 days of estrogen priming. Scopolamine did not significantly reduce other female sexual behaviors. Additionally, significant decreases in the number of mounts and intromissions, but not hip touches, were displayed by males exposed to scopolamine-treated females. This research suggests the possibility of a central cholinergic mechanism regulating female sexual behavior in rhesus monkeys. However, the general nature and duration of the cholinergic regulation of primate female sexual behavior differs substantially when compared to rodent behavior." @default.
- W2064967874 created "2016-06-24" @default.
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- W2064967874 date "1999-08-01" @default.
- W2064967874 modified "2023-09-23" @default.
- W2064967874 title "Scopolamine Inhibition of Female Sexual Behavior in Rhesus Monkeys (Macaca mulatta)" @default.
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- W2064967874 doi "https://doi.org/10.1016/s0091-3057(99)00035-0" @default.
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