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• W2064976319 abstract "Epigenetic parameters linked to E-cadherin gene were investigated in 5 human colorectal cancer cell lines. Treatment with trichostatin A led to enhanced acetylation of histone H3-K9 with concurrent induction of E-cadherin mRNA in 3 E-cadherin low/negative cell lines that are not DNA methylated. Co-treatment with 5-aza-2′-deoxycytidine and trichostatin A resulted in additive/synergic induction of E-cadherin mRNA in all 5 cell lines with concomitant enhancement of histone H3-K9 acetylation in 4 E-cadherin low/negative cell lines. Our results suggest that histone H3-K9 deacetylation appears to play a crucial role in transcriptional repression of E-cadherin in colorectal cancers." @default.
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• W2064976319 date "2008-01-01" @default.
• W2064976319 modified "2023-10-17" @default.
• W2064976319 title "Histone H3 (lys-9) Deacetylation is Associated with Transcriptional Silencing of E-cadherin in Colorectal Cancer Cell Lines" @default.
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• W2064976319 doi "https://doi.org/10.1080/07357900701837168" @default.
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