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- W2064977237 abstract "Different extracts (ethanolic, hexane, aqueous) of ginger (rhizomes of Zingiber officinale) and the essential oil were tested using [14C]guanidinium influx into N1E-115 cells and the isolated rat ileum in order to identify their activity in inhibiting 5-HT3 receptor function. The hexane extract proved to be the most active and yielded upon bioassay-guided fractionation nine constituents: [6]-, [8]-, [10]-gingerols, [6]- and [8]-shogaols which were previously shown as active in vivo against cytotoxic drug-induced emesis; [4]-gingerol, [6]-gingerdiol, diacetyl-[6]-gingerdiol and [6]-dehydrogingerdione have not been previously tested for anti-emetic or 5-HT3 receptor antagonistic effects. Even though the latter four compounds are only minor constituents, their identification contributed towards the characterisation of a structure-activity relationship of this class of compounds. The order of potency for the nine constituents in the N1E-115 cell system was [6]-gingerdiol ≈ diacetyl-[6]-gingerdiol ≈ [6]-dehydrogingerdione ≈ [6]-shogaol ≥ [8]-shogaol ≈ [8]-gingerol > [10]-gingerol ≥ [6]-gingerol > [4]-gingerol." @default.
- W2064977237 created "2016-06-24" @default.
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- W2064977237 date "2005-07-01" @default.
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- W2064977237 title "5-HT<sub>3</sub>Receptor Blocking Activity of Arylalkanes Isolated from the Rhizome of<i>Zingiber officinale</i>" @default.
- W2064977237 doi "https://doi.org/10.1055/s-2005-871265" @default.
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