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• W2064981775 endingPage "410" @default.
• W2064981775 startingPage "401" @default.
• W2064981775 abstract "In the fruit fly, circadian behavior is controlled by a small number of specialized neurons, whose molecular clocks are relatively well known. However, much less is known about how these neurons communicate among themselves. In particular, only 1 circadian neuropeptide, pigment-dispersing factor (PDF), has been identified, and most aspects of its interaction with the molecular clock remain to be elucidated. Furthermore, it is speculated that many other peptides should contribute to circadian communication. We have developed a relatively detailed model of the 2 main groups of circadian pacemaker neurons (sLNvs and LNds) to investigate these issues. We have proposed many possible mechanisms for the interaction between the synchronization factors and the molecular clock, and we have compared the outputs with the experimental results reported in the literature both for the wild-type and PDF-null mutant. We have studied how different the properties of each neuron should be to account for the observations reported for the sLNvs in the mutant. We have found that only a few mechanisms, mostly related to the slowing down of nuclear entry of a circadian protein, can synchronize neurons that present these differences. Detailed immunofluorescent recordings have suggested that, whereas in the mutant, LNd neurons are synchronized, in the wild-type, a subset of the LNds oscillate faster than the rest. With our model, we find that a more likely explanation for the same observations is that this subset is being driven outside its synchronization range and displays therefore a complex pattern of oscillation." @default.
• W2064981775 created "2016-06-24" @default.
• W2064981775 creator A5001975124 @default.
• W2064981775 creator A5034239775 @default.
• W2064981775 date "2014-11-21" @default.
• W2064981775 modified "2023-10-07" @default.
• W2064981775 title "A Mathematical Model of Communication between Groups of Circadian Neurons in Drosophila melanogaster" @default.
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• W2064981775 doi "https://doi.org/10.1177/0748730414557865" @default.
• W2064981775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25416595" @default.
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