Matches in SemOpenAlex for { <https://semopenalex.org/work/W2064992785> ?p ?o ?g. }
- W2064992785 endingPage "4877" @default.
- W2064992785 startingPage "4870" @default.
- W2064992785 abstract "This study reports the use of variants of coherent anti-Stokes Raman scattering (CARS) microscopy as a novel method for improved physicochemical characterization of drug-loaded silica particles. Ordered mesoporous silica is a biomaterial that can be loaded to carry a number of biochemicals, including poorly water-soluble drugs, by allowing the incorporation of drug into nanometer-sized pores. In this work, the loading of two poorly water-soluble model drugs, itraconazole and griseofulvin, in MCM-41 silica microparticles is characterized qualitatively, using the novel approach of CARS microscopy, which has advantages over other analytical approaches used to date and is non-destructive, rapid, label free, confocal and has chemical and physical specificity. The study investigated the effect of two solvent-based loading methods, namely immersion and rotary evaporation, and microparticle size on the three-dimensional (3-D) distribution of the two loaded drugs. Additionally, hyperspectral CARS microscopy was used to confirm the amorphous nature of the loaded drugs. Z-stacked CARS microscopy suggested that the drug, but not the loading method or particle size range, affected 3-D drug distribution. Hyperspectral CARS confirmed that the drug loaded in the MCM-41 silica microparticles was in an amorphous form. The results show that CARS microscopy and hyperspectral CARS microscopy can be used to provide further insights into the structural nature of loaded mesoporous silica microparticles as biomaterials." @default.
- W2064992785 created "2016-06-24" @default.
- W2064992785 creator A5025662276 @default.
- W2064992785 creator A5035901179 @default.
- W2064992785 creator A5037700634 @default.
- W2064992785 creator A5061191508 @default.
- W2064992785 creator A5071356523 @default.
- W2064992785 creator A5082040463 @default.
- W2064992785 creator A5088629099 @default.
- W2064992785 date "2014-11-01" @default.
- W2064992785 modified "2023-10-06" @default.
- W2064992785 title "Coherent anti-Stokes Raman scattering microscopy driving the future of loaded mesoporous silica imaging" @default.
- W2064992785 cites W1210478381 @default.
- W2064992785 cites W1964107229 @default.
- W2064992785 cites W1965970894 @default.
- W2064992785 cites W1973040104 @default.
- W2064992785 cites W1977775374 @default.
- W2064992785 cites W1989839235 @default.
- W2064992785 cites W1991178173 @default.
- W2064992785 cites W1994364077 @default.
- W2064992785 cites W1997552548 @default.
- W2064992785 cites W2000047433 @default.
- W2064992785 cites W2004278967 @default.
- W2064992785 cites W2005581291 @default.
- W2064992785 cites W2006369950 @default.
- W2064992785 cites W2008355493 @default.
- W2064992785 cites W2035765569 @default.
- W2064992785 cites W2039083422 @default.
- W2064992785 cites W2044594845 @default.
- W2064992785 cites W2049127690 @default.
- W2064992785 cites W2056362707 @default.
- W2064992785 cites W2071913543 @default.
- W2064992785 cites W2073595990 @default.
- W2064992785 cites W2086705246 @default.
- W2064992785 cites W2118769116 @default.
- W2064992785 cites W2137668635 @default.
- W2064992785 cites W2143334312 @default.
- W2064992785 cites W2143968399 @default.
- W2064992785 cites W2147163301 @default.
- W2064992785 cites W2161741006 @default.
- W2064992785 cites W2161915811 @default.
- W2064992785 cites W2163790025 @default.
- W2064992785 cites W2164454052 @default.
- W2064992785 cites W2314751267 @default.
- W2064992785 doi "https://doi.org/10.1016/j.actbio.2014.07.021" @default.
- W2064992785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25064000" @default.
- W2064992785 hasPublicationYear "2014" @default.
- W2064992785 type Work @default.
- W2064992785 sameAs 2064992785 @default.
- W2064992785 citedByCount "15" @default.
- W2064992785 countsByYear W20649927852015 @default.
- W2064992785 countsByYear W20649927852016 @default.
- W2064992785 countsByYear W20649927852017 @default.
- W2064992785 countsByYear W20649927852018 @default.
- W2064992785 countsByYear W20649927852020 @default.
- W2064992785 countsByYear W20649927852021 @default.
- W2064992785 crossrefType "journal-article" @default.
- W2064992785 hasAuthorship W2064992785A5025662276 @default.
- W2064992785 hasAuthorship W2064992785A5035901179 @default.
- W2064992785 hasAuthorship W2064992785A5037700634 @default.
- W2064992785 hasAuthorship W2064992785A5061191508 @default.
- W2064992785 hasAuthorship W2064992785A5071356523 @default.
- W2064992785 hasAuthorship W2064992785A5082040463 @default.
- W2064992785 hasAuthorship W2064992785A5088629099 @default.
- W2064992785 hasBestOaLocation W20649927852 @default.
- W2064992785 hasConcept C111368507 @default.
- W2064992785 hasConcept C120665830 @default.
- W2064992785 hasConcept C121332964 @default.
- W2064992785 hasConcept C127313418 @default.
- W2064992785 hasConcept C127413603 @default.
- W2064992785 hasConcept C147080431 @default.
- W2064992785 hasConcept C159078339 @default.
- W2064992785 hasConcept C159985019 @default.
- W2064992785 hasConcept C161790260 @default.
- W2064992785 hasConcept C169573571 @default.
- W2064992785 hasConcept C171250308 @default.
- W2064992785 hasConcept C178790620 @default.
- W2064992785 hasConcept C185592680 @default.
- W2064992785 hasConcept C192562407 @default.
- W2064992785 hasConcept C2777496208 @default.
- W2064992785 hasConcept C2777521759 @default.
- W2064992785 hasConcept C2778517922 @default.
- W2064992785 hasConcept C2779178360 @default.
- W2064992785 hasConcept C2779820397 @default.
- W2064992785 hasConcept C2987860518 @default.
- W2064992785 hasConcept C40003534 @default.
- W2064992785 hasConcept C42360764 @default.
- W2064992785 hasConcept C62649853 @default.
- W2064992785 hasConcept C77066764 @default.
- W2064992785 hasConcept C82776694 @default.
- W2064992785 hasConceptScore W2064992785C111368507 @default.
- W2064992785 hasConceptScore W2064992785C120665830 @default.
- W2064992785 hasConceptScore W2064992785C121332964 @default.
- W2064992785 hasConceptScore W2064992785C127313418 @default.
- W2064992785 hasConceptScore W2064992785C127413603 @default.
- W2064992785 hasConceptScore W2064992785C147080431 @default.
- W2064992785 hasConceptScore W2064992785C159078339 @default.
- W2064992785 hasConceptScore W2064992785C159985019 @default.