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- W2065009470 abstract "In this report, we have examined the role of neuron-derived BDNF at an accessible synapse, that of preganglionic neurons onto their sympathetic neuron targets. Developing and mature sympathetic neurons synthesize BDNF, and preganglionic neurons express the full-length BDNF/TrkB receptor. When sympathetic neuron-derived BDNF is increased 2- to 4-fold in transgenic mice, preganglionic cell bodies and axons hypertrophy, and the synaptic innervation to sympathetic neurons is increased. Conversely, when BDNF synthesis is eliminated in BDNF -/- mice, preganglionic synaptic innervation to sympathetic neurons is decreased. Together these results indicate that variations in neuronal neurotrophin synthesis directly regulate neuronal circuitry by selectively modulating synaptic innervation density." @default.
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- W2065009470 date "1997-02-01" @default.
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- W2065009470 title "Synaptic Innervation Density Is Regulated by Neuron-Derived BDNF" @default.
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- W2065009470 doi "https://doi.org/10.1016/s0896-6273(00)80266-4" @default.
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