FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065018238> ?p ?o ?g. }

• W2065018238 abstract "Protein phosphatase 2A (PP2A), an Akt pathway inhibitor, is considered to be activated by methylation of its catalytic subunit. Also PP2A downregulation was proposed to take part in carcinogenesis. Recently, PP2A activation was shown to be activated in response to DNA damage. To obtain further information on the role of PP2A in tumors and response to DNA damage, we investigated the relationship between PP2A methylation and activity, cell proliferation, Akt activation, c-Myc expression and PTEN activity in B16 melanoma cells untreated and after chloroethylnitrosourea (CENU) treatment. In untreated cells, okadaic acid, an antagonist of PP2A methylation, inhibited PP2A activity, stimulated cell proliferation, increased Akt activation and c-Myc expression. Xylulose-5-phosphate, an agonist of PP2A methylation, increased PP2A activity, decreased cell proliferation, Akt activation and c-Myc expression. However, both PP2A methylation modulators increased PTEN activity. During the response to CENU treatment, PP2A methylation and activity were strongly increased, Akt activation and c-Myc expression were decreased. However PTEN activity was increased. After tumor cell growth recovery, these modifications were moderately decreased. PP2A methylation was quantified and correlated positively with PP2A activity, and negatively with criteria for cell aggressiveness (cell proliferation, Akt activation, c-Myc expression). Based on these data, PP2A methylation status controls PP2A activity and oncoproteins expression and PP2A is strongly activated after CENU treatment thus partly explaining the growth inhibition in response to this agent. It follows that PP2A promethylating agents are potential candidates for anticancer drugs." @default.
• W2065018238 created "2016-06-24" @default.
• W2065018238 creator A5016012559 @default.
• W2065018238 creator A5016441799 @default.
• W2065018238 creator A5043108540 @default.
• W2065018238 creator A5058311487 @default.
• W2065018238 creator A5071759888 @default.
• W2065018238 creator A5074855610 @default.
• W2065018238 creator A5090100742 @default.
• W2065018238 date "2008-01-01" @default.
• W2065018238 modified "2023-10-01" @default.
• W2065018238 title "PP2A activity is controlled by methylation and regulates oncoprotein expression in melanoma cells: A mechanism which participates in growth inhibition induced by chloroethylnitrosourea treatment" @default.
• W2065018238 cites W1487234933 @default.
• W2065018238 cites W1512809531 @default.
• W2065018238 cites W1530740282 @default.
• W2065018238 cites W1564414547 @default.
• W2065018238 cites W1565516646 @default.
• W2065018238 cites W1577838670 @default.
• W2065018238 cites W1604525432 @default.
• W2065018238 cites W1966133006 @default.
• W2065018238 cites W1978058405 @default.
• W2065018238 cites W1981076681 @default.
• W2065018238 cites W1991134224 @default.
• W2065018238 cites W1994362554 @default.
• W2065018238 cites W2006985176 @default.
• W2065018238 cites W2007702597 @default.
• W2065018238 cites W2012269771 @default.
• W2065018238 cites W2028083348 @default.
• W2065018238 cites W2028225825 @default.
• W2065018238 cites W2031683541 @default.
• W2065018238 cites W2035884810 @default.
• W2065018238 cites W2039847562 @default.
• W2065018238 cites W2042084973 @default.
• W2065018238 cites W2044604423 @default.
• W2065018238 cites W2049475256 @default.
• W2065018238 cites W2052609775 @default.
• W2065018238 cites W2057047980 @default.
• W2065018238 cites W2065786947 @default.
• W2065018238 cites W2076984061 @default.
• W2065018238 cites W2082661266 @default.
• W2065018238 cites W2085314493 @default.
• W2065018238 cites W2092809155 @default.
• W2065018238 cites W2095659495 @default.
• W2065018238 cites W2102752109 @default.
• W2065018238 cites W2105214585 @default.
• W2065018238 cites W2110581206 @default.
• W2065018238 cites W2120526364 @default.
• W2065018238 cites W2129192121 @default.
• W2065018238 cites W2130592046 @default.
• W2065018238 cites W2140947536 @default.
• W2065018238 cites W2142900506 @default.
• W2065018238 cites W2144083605 @default.
• W2065018238 cites W2156257249 @default.
• W2065018238 cites W2161810908 @default.
• W2065018238 cites W23662677 @default.
• W2065018238 cites W1715622423 @default.
• W2065018238 doi "https://doi.org/10.3892/ijo.32.1.49" @default.
• W2065018238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18097542" @default.
• W2065018238 hasPublicationYear "2008" @default.
• W2065018238 type Work @default.
• W2065018238 sameAs 2065018238 @default.
• W2065018238 citedByCount "23" @default.
• W2065018238 countsByYear W20650182382012 @default.
• W2065018238 countsByYear W20650182382014 @default.
• W2065018238 countsByYear W20650182382015 @default.
• W2065018238 countsByYear W20650182382016 @default.
• W2065018238 countsByYear W20650182382017 @default.
• W2065018238 countsByYear W20650182382018 @default.
• W2065018238 countsByYear W20650182382019 @default.
• W2065018238 countsByYear W20650182382020 @default.
• W2065018238 countsByYear W20650182382021 @default.
• W2065018238 countsByYear W20650182382022 @default.
• W2065018238 crossrefType "journal-article" @default.
• W2065018238 hasAuthorship W2065018238A5016012559 @default.
• W2065018238 hasAuthorship W2065018238A5016441799 @default.
• W2065018238 hasAuthorship W2065018238A5043108540 @default.
• W2065018238 hasAuthorship W2065018238A5058311487 @default.
• W2065018238 hasAuthorship W2065018238A5071759888 @default.
• W2065018238 hasAuthorship W2065018238A5074855610 @default.
• W2065018238 hasAuthorship W2065018238A5090100742 @default.
• W2065018238 hasBestOaLocation W20650182381 @default.
• W2065018238 hasConcept C104317684 @default.
• W2065018238 hasConcept C11960822 @default.
• W2065018238 hasConcept C150194340 @default.
• W2065018238 hasConcept C153911025 @default.
• W2065018238 hasConcept C178666793 @default.
• W2065018238 hasConcept C185592680 @default.
• W2065018238 hasConcept C190727270 @default.
• W2065018238 hasConcept C2777609662 @default.
• W2065018238 hasConcept C33288867 @default.
• W2065018238 hasConcept C389152 @default.
• W2065018238 hasConcept C502942594 @default.
• W2065018238 hasConcept C552990157 @default.
• W2065018238 hasConcept C55493867 @default.
• W2065018238 hasConcept C62112901 @default.
• W2065018238 hasConcept C62478195 @default.
• W2065018238 hasConcept C75217442 @default.
• W2065018238 hasConcept C86554907 @default.
• W2065018238 hasConcept C86803240 @default.
• W2065018238 hasConcept C95444343 @default.

• next