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- W2065022013 abstract "Background: Monochemotherapy with gemcitabine (Gem) is often the treatment of choice in elderly or poor performance status (PS) patients with advanced non-small cell lung cancer (NSCLC). Our study was aimed to assess the efficacy and tolerability of a modified schedule of Gem using a lower dose than standard. Patients and Methods: From May 2009 through December 2010, fifty patients (43 males and 7 females with a median age of 76 years ranging from 64 to 85) with advanced NSCLC (stage IIIB 34.0% and IV 66.0%) were enrolled. Histology was: squamous 39.6%, adenocarcinoma 31.2%, large cell 6.2%, undifferentiated 4.2%, undetermined 18.8%. Only eight patients (16.0%) had a WHO PS 0 whereas nineteen (38.0%) were PS 1 and eleven (46.0%) PS 2. All patients received first-line chemotherapy with 6 cycles of Gem 1000mg/sq on days 1 and 8 every 4 weeks. Results: At the time of analysis 35 patients were evaluable for response. Partial response (PR) was achieved in 7 patients (20.0%), stable disease >12 weeks (SD) in 16 (45.7%) whereas 12 had progressive disease (34.3%). Importantly, the clinical benefit rate (PR + SD) was 65.7%. Tumour markers (CEA and NSE) were high in 28 patients with a reduction in their values observed in 11 of them (39.3%). Both pain and PS improved in 6 patients (17.1%) whereas 19 (54.2%) had an improvement in pain with no worsening of PS. We observed only grade 2 WHO haematological toxicities including anemia, leucopenia, neutropenia and trombocytopenia. Not-neutropenic fever occurred in 4 patients (11.4%). Overall, we did not observe any not-haematological treatment-related event. Conclusions: Our data show that a modified schedule of Gem with a lower dose intensity than standard may be beneficial in terms of both disease control and tolerability when employed in elderly or PS 2 patients with advanced NSCLC." @default.
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- W2065022013 date "2011-09-01" @default.
- W2065022013 modified "2023-10-17" @default.
- W2065022013 title "9098 POSTER First-Line Modified Schedule of Gemcitabine With a Lower Dose Than Standard in Elderly or PS 2 Patients With Advanced Non-Small Cell Lung Cancer" @default.
- W2065022013 doi "https://doi.org/10.1016/s0959-8049(11)72410-8" @default.
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