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- W2065044384 abstract "In recent years, significant milestones have been reached in the field of transplantation through the development of immunosuppressive drugs that inhibit lymphocyte activation, cytokine signal transduction, and cellular proliferation. However, the widespread tissue distribution of the molecular targets exploited to date-calcineurin, mammalian target of rapamycin (mTOR), and inosine monophosphate dehydrogenase-produces an array of collateral toxicities. Avoiding these side effects requires new strategies that selectively block destructive immune responses: a fifth generation of immunosuppressants. These agents must target molecules that are critical for and specific to the adaptive immune response." @default.
- W2065044384 created "2016-06-24" @default.
- W2065044384 creator A5011704380 @default.
- W2065044384 date "2003-09-01" @default.
- W2065044384 modified "2023-09-25" @default.
- W2065044384 title "The emerging matrix of immunosuppressive agents" @default.
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- W2065044384 doi "https://doi.org/10.1016/s0041-1345(03)00837-6" @default.
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