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- W2065055368 abstract "In recent years, facilitated by rapid technological advances, we are becoming more adept at probing the molecular processes, which take place in the nucleus, that are crucial for the hierarchical regulation and organization of chromatin architecture. With an unprecedented level of resolution, a detailed atlas of chromosomal structures (histone displacement, variants, modifications, chromosome territories, and DNA looping) and mechanisms underlying their establishment, provides invaluable insight into physiological as well as pathological phenomena. In this review, we will focus on prostate cancer, a prevalent malignancy in men worldwide, and for which a curative treatment strategy is yet to be attained. We aim to catalog the most frequently observed oncogenic alterations associated with chromatin conformation, while emphasizing the TMPRSS2-ERG fusion, which is found in more than one-half of prostate cancer patients and its functions in compromising the chromatin landscape in prostate cancer." @default.
- W2065055368 created "2016-06-24" @default.
- W2065055368 creator A5025065161 @default.
- W2065055368 creator A5026756753 @default.
- W2065055368 creator A5042253576 @default.
- W2065055368 date "2014-05-01" @default.
- W2065055368 modified "2023-09-23" @default.
- W2065055368 title "Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer" @default.
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