Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065075239> ?p ?o ?g. }
- W2065075239 endingPage "190" @default.
- W2065075239 startingPage "185" @default.
- W2065075239 abstract "The action of porcine pancreatic phospholipase A2 towards fluorescent phospholipid analogs is either enhanced or suppressed by 4β-12-O-tetradecanoylphorbol-13-acetate (TPA), depending on the chemical structure of the substrate and the concentration of Ca2+. In the presence of nmolar Ca2+ concentrations increasing [TPA] enhanced by approx. 5-fold the rate of hydrolysis of the pyrene-labelled acidic alkyl-acyl phospholipid, 1-octacosanyl-2-[6-(pyrene-1-yl)] hexanoyl -sn-glycero-3-phosphatidylmethanol. Maximal effect was obtained at high TPA/substrate molar ratios approaching 1:2. In the presence of 4 mM CaCl2 maximal activation was reduced to ≈1.5-fold. With the corresponding phosphatidylcholine derivative as a substrate increasing [TPA] reduced fatty acid release maximally by 90% both at low [Ca2+] as well as in the presence of 4 mM CaCl2. Essentially identical results were obtained using 4α-TPA, a stereoisomer which does not activate protein kinase C." @default.
- W2065075239 created "2016-06-24" @default.
- W2065075239 creator A5071553338 @default.
- W2065075239 creator A5078596818 @default.
- W2065075239 date "1992-05-01" @default.
- W2065075239 modified "2023-09-24" @default.
- W2065075239 title "Substrate level modulation of the activity of phospholipase A2 in vitro by 12-O-tetradecanoylphorbol-13-acetate" @default.
- W2065075239 cites W1520069435 @default.
- W2065075239 cites W1522405441 @default.
- W2065075239 cites W1544177526 @default.
- W2065075239 cites W1586296071 @default.
- W2065075239 cites W1605916516 @default.
- W2065075239 cites W16075687 @default.
- W2065075239 cites W1630124633 @default.
- W2065075239 cites W1919360935 @default.
- W2065075239 cites W1947815351 @default.
- W2065075239 cites W1991867288 @default.
- W2065075239 cites W1992982609 @default.
- W2065075239 cites W1993282564 @default.
- W2065075239 cites W199761710 @default.
- W2065075239 cites W1998449881 @default.
- W2065075239 cites W2000441724 @default.
- W2065075239 cites W2008706763 @default.
- W2065075239 cites W2018227955 @default.
- W2065075239 cites W2024314179 @default.
- W2065075239 cites W2027011134 @default.
- W2065075239 cites W2030549092 @default.
- W2065075239 cites W2051803128 @default.
- W2065075239 cites W2064370238 @default.
- W2065075239 cites W2065293020 @default.
- W2065075239 cites W2074444227 @default.
- W2065075239 cites W2079553385 @default.
- W2065075239 cites W2080550444 @default.
- W2065075239 cites W2082810423 @default.
- W2065075239 cites W2084271315 @default.
- W2065075239 cites W2114634890 @default.
- W2065075239 cites W2136702130 @default.
- W2065075239 cites W2315939327 @default.
- W2065075239 cites W2323350104 @default.
- W2065075239 cites W2337130094 @default.
- W2065075239 cites W2340417218 @default.
- W2065075239 doi "https://doi.org/10.1016/s0006-291x(05)80973-8" @default.
- W2065075239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1599455" @default.
- W2065075239 hasPublicationYear "1992" @default.
- W2065075239 type Work @default.
- W2065075239 sameAs 2065075239 @default.
- W2065075239 citedByCount "4" @default.
- W2065075239 crossrefType "journal-article" @default.
- W2065075239 hasAuthorship W2065075239A5071553338 @default.
- W2065075239 hasAuthorship W2065075239A5078596818 @default.
- W2065075239 hasConcept C12927208 @default.
- W2065075239 hasConcept C178790620 @default.
- W2065075239 hasConcept C181199279 @default.
- W2065075239 hasConcept C185592680 @default.
- W2065075239 hasConcept C18903297 @default.
- W2065075239 hasConcept C195794163 @default.
- W2065075239 hasConcept C202751555 @default.
- W2065075239 hasConcept C2776330855 @default.
- W2065075239 hasConcept C2776551241 @default.
- W2065075239 hasConcept C2776888444 @default.
- W2065075239 hasConcept C2777168633 @default.
- W2065075239 hasConcept C2777289219 @default.
- W2065075239 hasConcept C2778078955 @default.
- W2065075239 hasConcept C2778918659 @default.
- W2065075239 hasConcept C2778951431 @default.
- W2065075239 hasConcept C3017695315 @default.
- W2065075239 hasConcept C41625074 @default.
- W2065075239 hasConcept C55493867 @default.
- W2065075239 hasConcept C71240020 @default.
- W2065075239 hasConcept C86803240 @default.
- W2065075239 hasConcept C94412978 @default.
- W2065075239 hasConceptScore W2065075239C12927208 @default.
- W2065075239 hasConceptScore W2065075239C178790620 @default.
- W2065075239 hasConceptScore W2065075239C181199279 @default.
- W2065075239 hasConceptScore W2065075239C185592680 @default.
- W2065075239 hasConceptScore W2065075239C18903297 @default.
- W2065075239 hasConceptScore W2065075239C195794163 @default.
- W2065075239 hasConceptScore W2065075239C202751555 @default.
- W2065075239 hasConceptScore W2065075239C2776330855 @default.
- W2065075239 hasConceptScore W2065075239C2776551241 @default.
- W2065075239 hasConceptScore W2065075239C2776888444 @default.
- W2065075239 hasConceptScore W2065075239C2777168633 @default.
- W2065075239 hasConceptScore W2065075239C2777289219 @default.
- W2065075239 hasConceptScore W2065075239C2778078955 @default.
- W2065075239 hasConceptScore W2065075239C2778918659 @default.
- W2065075239 hasConceptScore W2065075239C2778951431 @default.
- W2065075239 hasConceptScore W2065075239C3017695315 @default.
- W2065075239 hasConceptScore W2065075239C41625074 @default.
- W2065075239 hasConceptScore W2065075239C55493867 @default.
- W2065075239 hasConceptScore W2065075239C71240020 @default.
- W2065075239 hasConceptScore W2065075239C86803240 @default.
- W2065075239 hasConceptScore W2065075239C94412978 @default.
- W2065075239 hasIssue "1" @default.
- W2065075239 hasLocation W20650752391 @default.
- W2065075239 hasLocation W20650752392 @default.
- W2065075239 hasOpenAccess W2065075239 @default.
- W2065075239 hasPrimaryLocation W20650752391 @default.
- W2065075239 hasRelatedWork W2040595849 @default.