Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065075987> ?p ?o ?g. }
- W2065075987 endingPage "606" @default.
- W2065075987 startingPage "600" @default.
- W2065075987 abstract "The synthesis and some pharmacological properties of 4-(3‘α-15‘β-dihydroxy-5β-estran-17‘β-yl)furan-2-methyl alcohol (16) have been described. The compound was synthesized by reacting a synthetic 3α- benzyloxy-5β-estr-15-en-17-one with the ethylene acetal of 4-bromo-2-furancarboxyaldehyde, followed by hydrolysis of the ethylene acetal and reduction of the aldehyde. Despite its resemblance to the structure of cardiac steroids (CS), 16 does not bind to the CS receptor on Na+,K+-ATPase and does not increase the force of contraction of heart muscle. However, 16 inhibited the digoxin-induced increase in the force of contraction and arrhythmias in guinea pig papillary muscle and human atrial appendages. The steroid also inhibited digoxin-induced alteration in endocytosed membrane traffic, indicating a novel mechanism of action." @default.
- W2065075987 created "2016-06-24" @default.
- W2065075987 creator A5020433042 @default.
- W2065075987 creator A5031268201 @default.
- W2065075987 creator A5031952014 @default.
- W2065075987 creator A5032595840 @default.
- W2065075987 creator A5035770330 @default.
- W2065075987 creator A5048017141 @default.
- W2065075987 creator A5063933715 @default.
- W2065075987 creator A5066301276 @default.
- W2065075987 creator A5088200518 @default.
- W2065075987 date "2005-12-20" @default.
- W2065075987 modified "2023-09-26" @default.
- W2065075987 title "4-(3‘α15‘β-Dihydroxy-5‘β-estran-17‘β-yl)furan-2-methyl Alcohol: An Anti-Digoxin Agent with a Novel Mechanism of Action" @default.
- W2065075987 cites W1526786728 @default.
- W2065075987 cites W1966809056 @default.
- W2065075987 cites W1977679531 @default.
- W2065075987 cites W1979679436 @default.
- W2065075987 cites W1988824422 @default.
- W2065075987 cites W1991662698 @default.
- W2065075987 cites W2003864480 @default.
- W2065075987 cites W2006666270 @default.
- W2065075987 cites W2009950502 @default.
- W2065075987 cites W2017277468 @default.
- W2065075987 cites W2020046541 @default.
- W2065075987 cites W2065863714 @default.
- W2065075987 cites W2069595524 @default.
- W2065075987 cites W2079232032 @default.
- W2065075987 cites W2086191277 @default.
- W2065075987 cites W2093555384 @default.
- W2065075987 cites W2156612859 @default.
- W2065075987 cites W2162348041 @default.
- W2065075987 cites W2168694728 @default.
- W2065075987 doi "https://doi.org/10.1021/jm0505819" @default.
- W2065075987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16420045" @default.
- W2065075987 hasPublicationYear "2005" @default.
- W2065075987 type Work @default.
- W2065075987 sameAs 2065075987 @default.
- W2065075987 citedByCount "10" @default.
- W2065075987 countsByYear W20650759872014 @default.
- W2065075987 countsByYear W20650759872016 @default.
- W2065075987 countsByYear W20650759872017 @default.
- W2065075987 countsByYear W20650759872019 @default.
- W2065075987 countsByYear W20650759872022 @default.
- W2065075987 countsByYear W20650759872023 @default.
- W2065075987 crossrefType "journal-article" @default.
- W2065075987 hasAuthorship W2065075987A5020433042 @default.
- W2065075987 hasAuthorship W2065075987A5031268201 @default.
- W2065075987 hasAuthorship W2065075987A5031952014 @default.
- W2065075987 hasAuthorship W2065075987A5032595840 @default.
- W2065075987 hasAuthorship W2065075987A5035770330 @default.
- W2065075987 hasAuthorship W2065075987A5048017141 @default.
- W2065075987 hasAuthorship W2065075987A5063933715 @default.
- W2065075987 hasAuthorship W2065075987A5066301276 @default.
- W2065075987 hasAuthorship W2065075987A5088200518 @default.
- W2065075987 hasConcept C126322002 @default.
- W2065075987 hasConcept C161790260 @default.
- W2065075987 hasConcept C163415756 @default.
- W2065075987 hasConcept C178790620 @default.
- W2065075987 hasConcept C185592680 @default.
- W2065075987 hasConcept C202751555 @default.
- W2065075987 hasConcept C2776120743 @default.
- W2065075987 hasConcept C2777707475 @default.
- W2065075987 hasConcept C2777731525 @default.
- W2065075987 hasConcept C2778198053 @default.
- W2065075987 hasConcept C2778659115 @default.
- W2065075987 hasConcept C2779825165 @default.
- W2065075987 hasConcept C2781066024 @default.
- W2065075987 hasConcept C55493867 @default.
- W2065075987 hasConcept C71240020 @default.
- W2065075987 hasConcept C71924100 @default.
- W2065075987 hasConceptScore W2065075987C126322002 @default.
- W2065075987 hasConceptScore W2065075987C161790260 @default.
- W2065075987 hasConceptScore W2065075987C163415756 @default.
- W2065075987 hasConceptScore W2065075987C178790620 @default.
- W2065075987 hasConceptScore W2065075987C185592680 @default.
- W2065075987 hasConceptScore W2065075987C202751555 @default.
- W2065075987 hasConceptScore W2065075987C2776120743 @default.
- W2065075987 hasConceptScore W2065075987C2777707475 @default.
- W2065075987 hasConceptScore W2065075987C2777731525 @default.
- W2065075987 hasConceptScore W2065075987C2778198053 @default.
- W2065075987 hasConceptScore W2065075987C2778659115 @default.
- W2065075987 hasConceptScore W2065075987C2779825165 @default.
- W2065075987 hasConceptScore W2065075987C2781066024 @default.
- W2065075987 hasConceptScore W2065075987C55493867 @default.
- W2065075987 hasConceptScore W2065075987C71240020 @default.
- W2065075987 hasConceptScore W2065075987C71924100 @default.
- W2065075987 hasIssue "2" @default.
- W2065075987 hasLocation W20650759871 @default.
- W2065075987 hasLocation W20650759872 @default.
- W2065075987 hasOpenAccess W2065075987 @default.
- W2065075987 hasPrimaryLocation W20650759871 @default.
- W2065075987 hasRelatedWork W1965100914 @default.
- W2065075987 hasRelatedWork W2025481864 @default.
- W2065075987 hasRelatedWork W2065075987 @default.
- W2065075987 hasRelatedWork W2313343923 @default.
- W2065075987 hasRelatedWork W2315730288 @default.
- W2065075987 hasRelatedWork W2549233020 @default.