Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065102742> ?p ?o ?g. }
- W2065102742 endingPage "2980" @default.
- W2065102742 startingPage "2973" @default.
- W2065102742 abstract "Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and inactivates its transcriptional activation and apoptotic functions. Here, we examined the level of mortalin expression in a large variety of tumor tissues, tumor-derived and in vitro immortalized human cells. It was elevated in many human tumors, and in all of the tumor-derived and in vitro immortalized cells. In human embryonic fibroblasts immortalized with an expression plasmid for hTERT, the telomerase catalytic subunit, with or without human papillomavirus E6 and E7 genes, we found that subclones with spontaneously increased mortalin expression levels became anchorage-independent and acquired the ability to form tumors in nude mice. Furthermore, overexpression of mortalin was sufficient to increase the malignancy of breast carcinoma cells. The study demonstrates that upregulation of mortalin contributes significantly to tumorigenesis, and thus is a good candidate target for cancer therapy. © 2006 Wiley-Liss, Inc." @default.
- W2065102742 created "2016-06-24" @default.
- W2065102742 creator A5029881104 @default.
- W2065102742 creator A5050482798 @default.
- W2065102742 creator A5053340529 @default.
- W2065102742 creator A5059888683 @default.
- W2065102742 creator A5070969494 @default.
- W2065102742 creator A5073459160 @default.
- W2065102742 creator A5081386846 @default.
- W2065102742 date "2006-01-01" @default.
- W2065102742 modified "2023-10-18" @default.
- W2065102742 title "Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis" @default.
- W2065102742 cites W1484388505 @default.
- W2065102742 cites W1490486327 @default.
- W2065102742 cites W1571737640 @default.
- W2065102742 cites W1574658543 @default.
- W2065102742 cites W1968325292 @default.
- W2065102742 cites W1973743644 @default.
- W2065102742 cites W1978968003 @default.
- W2065102742 cites W1986730481 @default.
- W2065102742 cites W1988399174 @default.
- W2065102742 cites W2002210017 @default.
- W2065102742 cites W2006115876 @default.
- W2065102742 cites W2007344133 @default.
- W2065102742 cites W2010534631 @default.
- W2065102742 cites W2014951277 @default.
- W2065102742 cites W2016059444 @default.
- W2065102742 cites W2023657121 @default.
- W2065102742 cites W2028020283 @default.
- W2065102742 cites W2028382897 @default.
- W2065102742 cites W2038957369 @default.
- W2065102742 cites W2044439936 @default.
- W2065102742 cites W2047898830 @default.
- W2065102742 cites W2055644050 @default.
- W2065102742 cites W2059280132 @default.
- W2065102742 cites W2063377605 @default.
- W2065102742 cites W2063541891 @default.
- W2065102742 cites W2075858745 @default.
- W2065102742 cites W2091349625 @default.
- W2065102742 cites W2098147003 @default.
- W2065102742 cites W2099317703 @default.
- W2065102742 cites W2100437915 @default.
- W2065102742 cites W2108222414 @default.
- W2065102742 cites W2108482850 @default.
- W2065102742 cites W2108987359 @default.
- W2065102742 cites W2118136186 @default.
- W2065102742 cites W2125007784 @default.
- W2065102742 cites W2132968032 @default.
- W2065102742 cites W2141122353 @default.
- W2065102742 cites W2152044215 @default.
- W2065102742 cites W2161277185 @default.
- W2065102742 cites W2171032298 @default.
- W2065102742 cites W2330120499 @default.
- W2065102742 cites W4232806396 @default.
- W2065102742 cites W4256285583 @default.
- W2065102742 doi "https://doi.org/10.1002/ijc.21773" @default.
- W2065102742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16425258" @default.
- W2065102742 hasPublicationYear "2006" @default.
- W2065102742 type Work @default.
- W2065102742 sameAs 2065102742 @default.
- W2065102742 citedByCount "209" @default.
- W2065102742 countsByYear W20651027422012 @default.
- W2065102742 countsByYear W20651027422013 @default.
- W2065102742 countsByYear W20651027422014 @default.
- W2065102742 countsByYear W20651027422015 @default.
- W2065102742 countsByYear W20651027422016 @default.
- W2065102742 countsByYear W20651027422017 @default.
- W2065102742 countsByYear W20651027422018 @default.
- W2065102742 countsByYear W20651027422019 @default.
- W2065102742 countsByYear W20651027422020 @default.
- W2065102742 countsByYear W20651027422021 @default.
- W2065102742 countsByYear W20651027422022 @default.
- W2065102742 countsByYear W20651027422023 @default.
- W2065102742 crossrefType "journal-article" @default.
- W2065102742 hasAuthorship W2065102742A5029881104 @default.
- W2065102742 hasAuthorship W2065102742A5050482798 @default.
- W2065102742 hasAuthorship W2065102742A5053340529 @default.
- W2065102742 hasAuthorship W2065102742A5059888683 @default.
- W2065102742 hasAuthorship W2065102742A5070969494 @default.
- W2065102742 hasAuthorship W2065102742A5073459160 @default.
- W2065102742 hasAuthorship W2065102742A5081386846 @default.
- W2065102742 hasConcept C104317684 @default.
- W2065102742 hasConcept C121608353 @default.
- W2065102742 hasConcept C125593758 @default.
- W2065102742 hasConcept C127561419 @default.
- W2065102742 hasConcept C153911025 @default.
- W2065102742 hasConcept C179185449 @default.
- W2065102742 hasConcept C202751555 @default.
- W2065102742 hasConcept C502942594 @default.
- W2065102742 hasConcept C54009773 @default.
- W2065102742 hasConcept C54355233 @default.
- W2065102742 hasConcept C555283112 @default.
- W2065102742 hasConcept C81885089 @default.
- W2065102742 hasConcept C86803240 @default.
- W2065102742 hasConcept C94581717 @default.
- W2065102742 hasConceptScore W2065102742C104317684 @default.
- W2065102742 hasConceptScore W2065102742C121608353 @default.
- W2065102742 hasConceptScore W2065102742C125593758 @default.