FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065103487> ?p ?o ?g. }

• W2065103487 endingPage "798" @default.
• W2065103487 startingPage "789" @default.
• W2065103487 abstract "Of the several latex proteins cloned and expressed, the rubber elongation factor, Hev b 1, and the closely related Hev b 3, represent two major allergens associated with latex allergy. Although both allergens demonstrated IgE binding with sera from latex allergic patients, it was not known whether these two molecules shared any epitopes. Hence, in the present study using health care workers (HCW) and spina bifida (SB) patients with latex allergy, we investigated the IgE binding epitopes in Hev b 1 and Hev b 3. Recombinant Hev b 1 and Hev b 3 were expressed in a prokaryotic expression system, while overlapping decapeptides of Hev b 1 and Hev b 3 were synthesized on derivatized cellulose membrane. Eight IgE binding epitopes for Hev b 1 and eleven for Hev b 3 were identified using sera from latex allergic patients with SB. On further analysis of synthetic peptides encompassing these epitopes, similar IgE antibody reactivity was demonstrated with three Hev b 1 epitopes b1E3, b1E5, b1E6 and two Hev b 3 epitopes; b3E10 and b3E 11. For Hev b 1, a unique IgE binding epitope was identified in the region of amino acid residues 16-25. In competitive ELISA, peptides bIE2 and bIE4 together inhibited 58% of IgE binding of Hev b 1, while b3E5 showed 22% inhibition in the IgE binding of Hev b 3. The results of the present study suggest that the understanding of linear and conformational IgE epitopes in the major latex allergens may provide better insight into the structure-function relationship of the allergens, and may lead to the development of better patient care and management strategies in latex allergy." @default.
• W2065103487 created "2016-06-24" @default.
• W2065103487 creator A5000720236 @default.
• W2065103487 creator A5012334539 @default.
• W2065103487 creator A5017111148 @default.
• W2065103487 creator A5032289252 @default.
• W2065103487 creator A5039769192 @default.
• W2065103487 creator A5049670143 @default.
• W2065103487 creator A5083184959 @default.
• W2065103487 date "2000-09-01" @default.
• W2065103487 modified "2023-10-01" @default.
• W2065103487 title "Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy" @default.
• W2065103487 cites W1523254402 @default.
• W2065103487 cites W1557035750 @default.
• W2065103487 cites W1558813989 @default.
• W2065103487 cites W1568951889 @default.
• W2065103487 cites W1580614078 @default.
• W2065103487 cites W1832935236 @default.
• W2065103487 cites W1979337702 @default.
• W2065103487 cites W1981940286 @default.
• W2065103487 cites W1982139844 @default.
• W2065103487 cites W1984265835 @default.
• W2065103487 cites W1986583696 @default.
• W2065103487 cites W1986661201 @default.
• W2065103487 cites W1989717385 @default.
• W2065103487 cites W1994130839 @default.
• W2065103487 cites W2008378932 @default.
• W2065103487 cites W2017152314 @default.
• W2065103487 cites W2028600874 @default.
• W2065103487 cites W2030212989 @default.
• W2065103487 cites W2035237551 @default.
• W2065103487 cites W2045840120 @default.
• W2065103487 cites W2046137918 @default.
• W2065103487 cites W2050324033 @default.
• W2065103487 cites W2062502515 @default.
• W2065103487 cites W2066375846 @default.
• W2065103487 cites W2075586481 @default.
• W2065103487 cites W2088657785 @default.
• W2065103487 cites W2090430118 @default.
• W2065103487 cites W2092564708 @default.
• W2065103487 cites W2118286632 @default.
• W2065103487 cites W2123994079 @default.
• W2065103487 cites W2138270253 @default.
• W2065103487 cites W2145533125 @default.
• W2065103487 cites W2155240550 @default.
• W2065103487 cites W2394884560 @default.
• W2065103487 cites W3161889742 @default.
• W2065103487 doi "https://doi.org/10.1016/s0161-5890(00)00095-x" @default.
• W2065103487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11275264" @default.
• W2065103487 hasPublicationYear "2000" @default.
• W2065103487 type Work @default.
• W2065103487 sameAs 2065103487 @default.
• W2065103487 citedByCount "28" @default.
• W2065103487 countsByYear W20651034872012 @default.
• W2065103487 countsByYear W20651034872013 @default.
• W2065103487 countsByYear W20651034872014 @default.
• W2065103487 countsByYear W20651034872015 @default.
• W2065103487 countsByYear W20651034872016 @default.
• W2065103487 countsByYear W20651034872023 @default.
• W2065103487 crossrefType "journal-article" @default.
• W2065103487 hasAuthorship W2065103487A5000720236 @default.
• W2065103487 hasAuthorship W2065103487A5012334539 @default.
• W2065103487 hasAuthorship W2065103487A5017111148 @default.
• W2065103487 hasAuthorship W2065103487A5032289252 @default.
• W2065103487 hasAuthorship W2065103487A5039769192 @default.
• W2065103487 hasAuthorship W2065103487A5049670143 @default.
• W2065103487 hasAuthorship W2065103487A5083184959 @default.
• W2065103487 hasConcept C141105273 @default.
• W2065103487 hasConcept C159047783 @default.
• W2065103487 hasConcept C159654299 @default.
• W2065103487 hasConcept C185592680 @default.
• W2065103487 hasConcept C195616568 @default.
• W2065103487 hasConcept C203014093 @default.
• W2065103487 hasConcept C207480886 @default.
• W2065103487 hasConcept C2780731369 @default.
• W2065103487 hasConcept C2781241564 @default.
• W2065103487 hasConcept C86803240 @default.
• W2065103487 hasConceptScore W2065103487C141105273 @default.
• W2065103487 hasConceptScore W2065103487C159047783 @default.
• W2065103487 hasConceptScore W2065103487C159654299 @default.
• W2065103487 hasConceptScore W2065103487C185592680 @default.
• W2065103487 hasConceptScore W2065103487C195616568 @default.
• W2065103487 hasConceptScore W2065103487C203014093 @default.
• W2065103487 hasConceptScore W2065103487C207480886 @default.
• W2065103487 hasConceptScore W2065103487C2780731369 @default.
• W2065103487 hasConceptScore W2065103487C2781241564 @default.
• W2065103487 hasConceptScore W2065103487C86803240 @default.
• W2065103487 hasIssue "12-13" @default.
• W2065103487 hasLocation W20651034871 @default.
• W2065103487 hasLocation W20651034872 @default.
• W2065103487 hasOpenAccess W2065103487 @default.
• W2065103487 hasPrimaryLocation W20651034871 @default.
• W2065103487 hasRelatedWork W1557035750 @default.
• W2065103487 hasRelatedWork W2000718765 @default.
• W2065103487 hasRelatedWork W2065103487 @default.
• W2065103487 hasRelatedWork W2147284095 @default.
• W2065103487 hasRelatedWork W2159865582 @default.
• W2065103487 hasRelatedWork W2165262752 @default.

• next