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• W2065113445 startingPage "1157" @default.
• W2065113445 abstract "Although most chemotherapeutic drugs have the potential to exert cardiotoxicity, these drugs have been chosen for use in cancer treatment because survival and curability benefits outweigh the risk of these complications. Anthracyclines, for example, are a powerful class of chemotherapeutic agents; however, their use is restricted by dose-related cardiotoxicity. Experimental evidence strongly supports the role of reactive oxygen species in this process, suggesting that antioxidants may be effective in protecting the heart from toxicity. Clinical use of antioxidants to protect the heart during anthracycline chemotherapy has been controversial due to the potential for reduced cytotoxic efficacy toward cancer cells. Results from randomized clinical trials addressing whether antioxidants either reduce the incidence of clinical heart failure among patients undergoing anthracycline-based chemotherapy or reduce the response rates to anthracycline-based chemotherapy have been unclear. While anthracyclines are by far the most well-studied antitumor agents with cardiotoxic properties, evidence now shows that reactive oxygen species may play roles in cardiotoxicity induced by other chemotherapeutic agents such as cyclophosphamide, cisplatin, 5-fluorouracil, and trastuzumab. Thus, in the new era of combination therapy and long-term survival of cancer patients, the use of antioxidants to support cancer therapy should be revisited." @default.
• W2065113445 created "2016-06-24" @default.
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• W2065113445 creator A5084686589 @default.
• W2065113445 date "2013-08-20" @default.
• W2065113445 modified "2023-10-17" @default.
• W2065113445 title "The role of antioxidants in the era of cardio-oncology" @default.
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• W2065113445 doi "https://doi.org/10.1007/s00280-013-2260-4" @default.
• W2065113445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3947340" @default.
• W2065113445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23959462" @default.
• W2065113445 hasPublicationYear "2013" @default.
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