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- W2065113713 abstract "Calcium ionophore A23187 produced a dose-dependent increase in plasma protein leakage on intradermal injection in rats. Studies with mepyramine and cyproheptadine indicated that histamine and 5-hydroxytryptamine (5-HT) partially contribute to the ionophore action and experiments with compound 48/80 supported these findings. Depletion of plasma kininogen levels with cellulose sulphate did not significantly inhibit the ionophore effect in rats suggesting that kinins are unimportant in the ionophore action. Orally administered indomethacin inhibited the ionophore response in a dose-dependent manner. The inhibition was not reversed by intradermally injected prostaglandin E2 (PGE2) in doses up to 50 ng/site, suggesting that PGE2 also may not be an important mediator. It is proposed that the ionophore produces plasma protein leakage by an indirect (through histamine and 5-HT release) and a direct action on vascular endothelial cells and that indomethacin antagonises both actions by inhibiting calcium transport processes." @default.
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- W2065113713 date "1982-06-01" @default.
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- W2065113713 title "Mechanism of ionophore A23187 induction of plasma protein leakage and of its inhibition by indomethacin" @default.
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- W2065113713 doi "https://doi.org/10.1016/0014-2999(82)90598-2" @default.
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