FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065117828> ?p ?o ?g. }

• W2065117828 endingPage "1371" @default.
• W2065117828 startingPage "1363" @default.
• W2065117828 abstract "Oxidative stress in retinal pigment epithelium (RPE) is one of the key causative factors of RPE injury in age-related macular degeneration (AMD). Low-intensity ultrasound (LIUS) less than 1 W/cm2 in intensity has been found to have cytoprotective and anti-inflammatory effects in many cell types and diseases. In this study, we investigated for the first time the feasibility of using LIUS to protect RPE cells from oxidative damage. ARPE-19 cells were treated with H2O2 (an exogenous source of reactive oxygen species) or L-buthionine-(S,R)-sulfoximine (BSO), a glutathione synthase inhibitor, and exposed immediately to LIUS at intensities of 50, 100 and 200 mW/cm2 and a frequency of 1 MHz for 20 min. Both H2O2 and BSO increased the percentage of cells positive for mitochondrial reactive oxygen species at 1 h, but not at 24 h. Co-treatment with LIUS clearly repressed these cells similarly at all intensities by approximately 34%–43% for H2O2 and 24%–25% for BSO (p < 0.05). The percentage of cells with mitochondrial membrane depolarization also increased with H2O2 and BSO treatment, particularly at 1 h, and decreased by approximately 60% with LIUS at 100 mW/cm2 (p < 0.05). The amount of intracellular calcium ion ([Ca2+]i) was elevated only by BSO at 24 h and was also significantly diminished, by approximately 45%, by LIUS at 100 mW/cm2 (p < 0.05). Both H2O2 and BSO significantly hampered cell viability at 24 h, but LIUS at 100 mW/cm2 restored only BSO-induced cell viability by approximately 2.7-fold (p < 0.05). This study illustrated that LIUS has a protective effect on RPE cells against oxidative damage caused by BSO, an endogenous mitochondrial reactive oxygen species generator. We speculate that LIUS has the potential to treat oxidative damage and related pathologic changes in RPE." @default.
• W2065117828 created "2016-06-24" @default.
• W2065117828 creator A5015132546 @default.
• W2065117828 creator A5053093722 @default.
• W2065117828 creator A5055736461 @default.
• W2065117828 creator A5079998981 @default.
• W2065117828 creator A5090269403 @default.
• W2065117828 date "2015-05-01" @default.
• W2065117828 modified "2023-09-25" @default.
• W2065117828 title "Effects of Low-Intensity Ultrasound on Oxidative Damage in Retinal Pigment Epithelial Cells in vitro" @default.
• W2065117828 cites W1487528435 @default.
• W2065117828 cites W1500939659 @default.
• W2065117828 cites W1535828429 @default.
• W2065117828 cites W1966856823 @default.
• W2065117828 cites W1968067390 @default.
• W2065117828 cites W1968899197 @default.
• W2065117828 cites W1969709153 @default.
• W2065117828 cites W1970528463 @default.
• W2065117828 cites W1978412174 @default.
• W2065117828 cites W1994369919 @default.
• W2065117828 cites W2002895237 @default.
• W2065117828 cites W2013299443 @default.
• W2065117828 cites W2021122140 @default.
• W2065117828 cites W2024422059 @default.
• W2065117828 cites W2029765361 @default.
• W2065117828 cites W2030628584 @default.
• W2065117828 cites W2036074037 @default.
• W2065117828 cites W2045411250 @default.
• W2065117828 cites W2050479734 @default.
• W2065117828 cites W2051690606 @default.
• W2065117828 cites W2057231541 @default.
• W2065117828 cites W2059569751 @default.
• W2065117828 cites W2076196604 @default.
• W2065117828 cites W2078488768 @default.
• W2065117828 cites W2083589965 @default.
• W2065117828 cites W2085768438 @default.
• W2065117828 cites W2091524107 @default.
• W2065117828 cites W2093636186 @default.
• W2065117828 cites W2094510532 @default.
• W2065117828 cites W2097721607 @default.
• W2065117828 cites W2103538685 @default.
• W2065117828 cites W2114443210 @default.
• W2065117828 cites W2135314348 @default.
• W2065117828 cites W2144839999 @default.
• W2065117828 cites W2155750504 @default.
• W2065117828 cites W2170804352 @default.
• W2065117828 cites W2170873515 @default.
• W2065117828 cites W4211214508 @default.
• W2065117828 doi "https://doi.org/10.1016/j.ultrasmedbio.2014.12.665" @default.
• W2065117828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25722027" @default.
• W2065117828 hasPublicationYear "2015" @default.
• W2065117828 type Work @default.
• W2065117828 sameAs 2065117828 @default.
• W2065117828 citedByCount "10" @default.
• W2065117828 countsByYear W20651178282016 @default.
• W2065117828 countsByYear W20651178282017 @default.
• W2065117828 countsByYear W20651178282018 @default.
• W2065117828 countsByYear W20651178282019 @default.
• W2065117828 countsByYear W20651178282020 @default.
• W2065117828 countsByYear W20651178282021 @default.
• W2065117828 countsByYear W20651178282022 @default.
• W2065117828 countsByYear W20651178282023 @default.
• W2065117828 crossrefType "journal-article" @default.
• W2065117828 hasAuthorship W2065117828A5015132546 @default.
• W2065117828 hasAuthorship W2065117828A5053093722 @default.
• W2065117828 hasAuthorship W2065117828A5055736461 @default.
• W2065117828 hasAuthorship W2065117828A5079998981 @default.
• W2065117828 hasAuthorship W2065117828A5090269403 @default.
• W2065117828 hasConcept C12554922 @default.
• W2065117828 hasConcept C1491633281 @default.
• W2065117828 hasConcept C153911025 @default.
• W2065117828 hasConcept C181199279 @default.
• W2065117828 hasConcept C185592680 @default.
• W2065117828 hasConcept C190283241 @default.
• W2065117828 hasConcept C2776151105 @default.
• W2065117828 hasConcept C2778024200 @default.
• W2065117828 hasConcept C2780827179 @default.
• W2065117828 hasConcept C4141045 @default.
• W2065117828 hasConcept C48349386 @default.
• W2065117828 hasConcept C538909803 @default.
• W2065117828 hasConcept C55493867 @default.
• W2065117828 hasConcept C57600042 @default.
• W2065117828 hasConcept C79879829 @default.
• W2065117828 hasConcept C86803240 @default.
• W2065117828 hasConceptScore W2065117828C12554922 @default.
• W2065117828 hasConceptScore W2065117828C1491633281 @default.
• W2065117828 hasConceptScore W2065117828C153911025 @default.
• W2065117828 hasConceptScore W2065117828C181199279 @default.
• W2065117828 hasConceptScore W2065117828C185592680 @default.
• W2065117828 hasConceptScore W2065117828C190283241 @default.
• W2065117828 hasConceptScore W2065117828C2776151105 @default.
• W2065117828 hasConceptScore W2065117828C2778024200 @default.
• W2065117828 hasConceptScore W2065117828C2780827179 @default.
• W2065117828 hasConceptScore W2065117828C4141045 @default.
• W2065117828 hasConceptScore W2065117828C48349386 @default.
• W2065117828 hasConceptScore W2065117828C538909803 @default.
• W2065117828 hasConceptScore W2065117828C55493867 @default.
• W2065117828 hasConceptScore W2065117828C57600042 @default.

• next