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- W2065120341 abstract "In two preliminary communications from this department (1, 2) the presence of a metabolic stimulant in pituitary extracts, other than the thyrotropic hormone, has been reported. This principle causes a sharp rise in oxygen consumption within a few hours after injection, with a corresponding fall in the respiratory quotient. Its probable identity with the melanophore hormone of the pars intermedia has been suggested. The present paper contains a more detailed account of the work on this subject. Previous workers have shown that pituitary extracts may stimulate metabolism even in thyroidectomized animals. Houssay and Artundo (3) found that in thyroidectomized dogs the metabolic response to pituitary extracts was reduced but still present. Gaebler (4), using an impure growth preparation in a single massive dose subcutaneously, showed a well-marked rise in oxygen consumption of thyroidectomized dogs, which was at a maximum after 24 hours and persisted for some days. The respiratory quotient remained low." @default.
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- W2065120341 date "1938-12-01" @default.
- W2065120341 modified "2023-10-14" @default.
- W2065120341 title "THE SPECIFIC METABOLIC PRINCIPLE OF THE PITUITARY, AND ITS RELATION TO THE MELANOPHORE HORMONE" @default.
- W2065120341 doi "https://doi.org/10.1210/endo-23-6-718" @default.
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