FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065133143> ?p ?o ?g. }

• W2065133143 endingPage "822" @default.
• W2065133143 startingPage "813" @default.
• W2065133143 abstract "To assess whether CYP2C9 alleles other than CYP2C9*2 and *3 are associated with a low-warfarin dose requirement and the relevance of upstream CYP2C9 polymorphisms to dose requirement and metabolism.CYP2C9 exons, intron-exon boundaries and 3 kb of upstream sequence in 20 patients requiring <or= 1.5 mg warfarin per day and with apparently homozygous wild-type or heterozygous CYP2C9*2 genotypes were screened for novel polymorphisms by single-strand conformational polymorphism analysis. PCR-based genotyping assays for novel upstream and other known polymorphisms were used to screen a larger patient population of known CYP2C9*2 and *3 genotype requiring a range of warfarin doses.Polymorphisms at eight different upstream sites were found, five of which were already described. We found that the majority of the upstream polymorphisms were in complete linkage disequilibrium with previously described coding region polymorphisms. However, two polymorphisms, T-1188C and the novel DeltaG-2664DeltaT-2665, occurred both in individuals who were otherwise wild-type and in individuals positive for coding region polymorphisms. Evidence for 11 haplotypes, including 8 with frequencies >or= 0.01, was obtained. In individuals negative for coding region polymorphisms, neither individual genotypes for T-1188C or DeltaG-2664DeltaT-2665 or particular combinations of haplotype pairs were predictive of dose requirement or S-warfarin total clearance, suggesting neither upstream polymorphism was functionally significant. Dose requirements in CYP2C9*11 heterozygotes were not statistically significantly different from homozygous wild-type individuals.The coding region non-synonymous polymorphisms associated with the CYP2C9*2 and CYP2C9*3 alleles are the major CYP2C9-related factor affecting warfarin dose in UK Caucasians. Upstream CYP2C9 polymorphisms do not appear to be important independent determinants of dose requirement." @default.
• W2065133143 created "2016-06-24" @default.
• W2065133143 creator A5009017786 @default.
• W2065133143 creator A5052049041 @default.
• W2065133143 creator A5058430177 @default.
• W2065133143 creator A5084012349 @default.
• W2065133143 creator A5085411512 @default.
• W2065133143 date "2004-12-01" @default.
• W2065133143 modified "2023-10-17" @default.
• W2065133143 title "Upstream and coding region CYP2C9 polymorphisms" @default.
• W2065133143 cites W1502407336 @default.
• W2065133143 cites W1614927947 @default.
• W2065133143 cites W179252842 @default.
• W2065133143 cites W1967796257 @default.
• W2065133143 cites W1969695802 @default.
• W2065133143 cites W1977244553 @default.
• W2065133143 cites W1977524804 @default.
• W2065133143 cites W1979862336 @default.
• W2065133143 cites W1981807730 @default.
• W2065133143 cites W1983000301 @default.
• W2065133143 cites W1984527120 @default.
• W2065133143 cites W1989810877 @default.
• W2065133143 cites W1994680746 @default.
• W2065133143 cites W1998269707 @default.
• W2065133143 cites W2015200660 @default.
• W2065133143 cites W2018422469 @default.
• W2065133143 cites W2020797824 @default.
• W2065133143 cites W2029327304 @default.
• W2065133143 cites W2029562489 @default.
• W2065133143 cites W2032406682 @default.
• W2065133143 cites W2037963439 @default.
• W2065133143 cites W2043671679 @default.
• W2065133143 cites W2044939869 @default.
• W2065133143 cites W2053863013 @default.
• W2065133143 cites W2056119097 @default.
• W2065133143 cites W2063102214 @default.
• W2065133143 cites W2065976317 @default.
• W2065133143 cites W2070921940 @default.
• W2065133143 cites W2072672709 @default.
• W2065133143 cites W2072766615 @default.
• W2065133143 cites W2092413769 @default.
• W2065133143 cites W2098025302 @default.
• W2065133143 cites W2109943085 @default.
• W2065133143 cites W2110755408 @default.
• W2065133143 cites W2111404714 @default.
• W2065133143 cites W2114169153 @default.
• W2065133143 cites W2118921958 @default.
• W2065133143 cites W2129665596 @default.
• W2065133143 cites W2136924569 @default.
• W2065133143 cites W2151774137 @default.
• W2065133143 cites W2164327527 @default.
• W2065133143 cites W2404353704 @default.
• W2065133143 cites W9190291 @default.
• W2065133143 doi "https://doi.org/10.1097/00008571-200412000-00004" @default.
• W2065133143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15608560" @default.
• W2065133143 hasPublicationYear "2004" @default.
• W2065133143 type Work @default.
• W2065133143 sameAs 2065133143 @default.
• W2065133143 citedByCount "91" @default.
• W2065133143 countsByYear W20651331432012 @default.
• W2065133143 countsByYear W20651331432013 @default.
• W2065133143 countsByYear W20651331432014 @default.
• W2065133143 countsByYear W20651331432015 @default.
• W2065133143 countsByYear W20651331432016 @default.
• W2065133143 countsByYear W20651331432017 @default.
• W2065133143 countsByYear W20651331432019 @default.
• W2065133143 countsByYear W20651331432020 @default.
• W2065133143 countsByYear W20651331432022 @default.
• W2065133143 crossrefType "journal-article" @default.
• W2065133143 hasAuthorship W2065133143A5009017786 @default.
• W2065133143 hasAuthorship W2065133143A5052049041 @default.
• W2065133143 hasAuthorship W2065133143A5058430177 @default.
• W2065133143 hasAuthorship W2065133143A5084012349 @default.
• W2065133143 hasAuthorship W2065133143A5085411512 @default.
• W2065133143 hasConcept C104317684 @default.
• W2065133143 hasConcept C135763542 @default.
• W2065133143 hasConcept C180754005 @default.
• W2065133143 hasConcept C197754878 @default.
• W2065133143 hasConcept C2908647359 @default.
• W2065133143 hasConcept C31467283 @default.
• W2065133143 hasConcept C35605836 @default.
• W2065133143 hasConcept C3946865 @default.
• W2065133143 hasConcept C54355233 @default.
• W2065133143 hasConcept C71924100 @default.
• W2065133143 hasConcept C86803240 @default.
• W2065133143 hasConcept C91779695 @default.
• W2065133143 hasConcept C99454951 @default.
• W2065133143 hasConceptScore W2065133143C104317684 @default.
• W2065133143 hasConceptScore W2065133143C135763542 @default.
• W2065133143 hasConceptScore W2065133143C180754005 @default.
• W2065133143 hasConceptScore W2065133143C197754878 @default.
• W2065133143 hasConceptScore W2065133143C2908647359 @default.
• W2065133143 hasConceptScore W2065133143C31467283 @default.
• W2065133143 hasConceptScore W2065133143C35605836 @default.
• W2065133143 hasConceptScore W2065133143C3946865 @default.
• W2065133143 hasConceptScore W2065133143C54355233 @default.
• W2065133143 hasConceptScore W2065133143C71924100 @default.
• W2065133143 hasConceptScore W2065133143C86803240 @default.

• next