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- W2065136593 abstract "To assess the hypothesis that angiogenic gene therapy with the genomic form of vascular endothelial growth factor (VEGF) expressing the three major isoforms could be more potent than a vector expressing a single isoform, we designed an adenovirus vector (AdVEGF-All) expressing a VEGF cDNA/genomic hybrid gene. AdVEGF-All expressed all three major isoforms (121, 165, 189) in a 2:2:1 ratio. AdVEGF-All was 100-fold more potent than cDNA vectors expressing VEGF 121, 165, or 189 in restoring blood flow to the ischemic mouse hind limb. Interestingly, a mixture of Ad vectors individually expressing the VEGF 121, 165, and 189 cDNAs was equipotent to an equivalent dose of AdVEGF-All. Thus, a mixture of VEGF isoforms provides a more potent angiogenic response than a single isoform, suggesting that the individual isoforms function synergistically, an observation with important implications for gene and recombinant protein therapy." @default.
- W2065136593 created "2016-06-24" @default.
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- W2065136593 date "2004-01-01" @default.
- W2065136593 modified "2023-10-08" @default.
- W2065136593 title "Adenovirus-Mediated Transfer of a Minigene Expressing Multiple Isoforms of VEGF Is More Effective at Inducing Angiogenesis Than Comparable Vectors Expressing Individual VEGF cDNAs" @default.
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- W2065136593 doi "https://doi.org/10.1016/j.ymthe.2003.09.014" @default.
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