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- W2065140384 abstract "Magnetic resonance (MR) measures have shown anatomical abnormalities in first episode schizophrenia, including reduced volumes in both temporal and prefrontal structures, and a reduction in overall neocortical gray matter. However, the specificity of the overall gray matter reduction to schizophrenia compared with other psychotic disorders was not clear. To determine the specificity of changes to schizophrenic psychosis, an automatic segmentation program was applied to high resolution MRI with affective psychosis subjects as a contrast group. MR images were obtained at first hospitalization from patients with schizophrenia (n = 23), and from age-matched subjects with affective psychosis (n = 29, n = 25 manic), and normal controls (n = 29). The intensity information from both the SPGR and T2 images was then used in a fully automated segmentation program to classify tissue into gray matter, white matter, or CSF. Subsequent manual editing separated neocortical from non-neocortical gray matter. (Medial temporal structures, i.e., amygdala and hippocampus, were excluded.) Lateral ventricles were also delineated. Repeated measures ANCOVA showed a GROUP × SIDE interaction based on relative volumes [(ROI volume/intra-cranial volume) × 100]. Follow up ANCOVA revealed that left cortical gray matter volume was significantly reduced in schizophrenia compared to affective psychotic subjects (3.8% reduction in schizophrenia) and normal controls (5.4% reduction in schizophrenia). Schizophrenia subjects also showed significant increases in CSF volume of subarachnoid space, 29.0% relative to affective psychosis and 43.3% relative to controls. These findings suggest that left hemisphere cortical gray abnormalities may be present at first hospitalization in schizophrenic but not in affective psychosis patients. Based on other data from our laboratory, this reduction may be relatively greater in temporal and frontal lobes." @default.
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- W2065140384 date "2000-04-01" @default.
- W2065140384 modified "2023-09-25" @default.
- W2065140384 title "341. Specificity of reduced cortical gray matter to first episode schizophrenic psychosis" @default.
- W2065140384 doi "https://doi.org/10.1016/s0006-3223(00)00605-3" @default.
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