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- W2065140692 endingPage "551" @default.
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- W2065140692 abstract "Abstract S100, a multigenic family of non‐ubiquitous Ca 2+ ‐modulated proteins of the EF‐hand type expressed in vertebrates exclusively, has been implicated in intracellular and extracellular regulatory activities. Members of this protein family have been shown to interact with several effector proteins within cells thereby regulating enzyme activities, the dynamics of cytoskeleton constituents, cell growth and differentiation, and Ca 2+ homeostasis. Structural information indicates that most of S100 proteins exist in the form of antiparallelly packed homodimers (in some cases heterodimers), capable of functionally crossbridging two homologous or heterologous target proteins in a Ca 2+ ‐dependent (and, in some instances, Ca 2+ ‐independent) manner. In addition, extracellular roles have been described for several S100 members, although secretion (via an unknown mechanism) has been documented for a few of them. Extracellular S100 proteins have been shown to exert regulatory effects on inflammatory cells, neurons, astrocytes, microglia, and endothelial and epithelial cells, and a cell surface receptor, RAGE, has been identified as a potential S100A12 and S100B receptor transducing the effects of these two proteins on inflammatory cells and neurons. Other cell surface molecules with ability to interact with S100 members have been identified, suggesting that RAGE might not be a universal S100 protein receptor and/or that a single S100 protein might interact with more than one receptor. Collectively, these data indicate that members of the S100 protein family are multifunctional proteins implicated in the regulation of a variety of cellular activities. Microsc. Res. Tech. 60:540–551, 2003. © 2003 Wiley‐Liss, Inc." @default.
- W2065140692 created "2016-06-24" @default.
- W2065140692 creator A5065739247 @default.
- W2065140692 date "2003-03-12" @default.
- W2065140692 modified "2023-10-18" @default.
- W2065140692 title "Intracellular and extracellular roles of S100 proteins" @default.
- W2065140692 cites W1491887612 @default.
- W2065140692 cites W1495865616 @default.
- W2065140692 cites W1550806901 @default.
- W2065140692 cites W1562745957 @default.
- W2065140692 cites W1570621401 @default.
- W2065140692 cites W1606815882 @default.
- W2065140692 cites W1608239929 @default.
- W2065140692 cites W1747561482 @default.
- W2065140692 cites W1867383795 @default.
- W2065140692 cites W1880127774 @default.
- W2065140692 cites W1897550668 @default.
- W2065140692 cites W1932669647 @default.
- W2065140692 cites W1945593336 @default.
- W2065140692 cites W1964605101 @default.
- W2065140692 cites W1965421783 @default.
- W2065140692 cites W1971431899 @default.
- W2065140692 cites W1974194572 @default.
- W2065140692 cites W1975035282 @default.
- W2065140692 cites W1976525474 @default.
- W2065140692 cites W1977945741 @default.
- W2065140692 cites W1980453745 @default.
- W2065140692 cites W1982612238 @default.
- W2065140692 cites W1982678490 @default.
- W2065140692 cites W1982703447 @default.
- W2065140692 cites W1985041752 @default.
- W2065140692 cites W1985871101 @default.
- W2065140692 cites W1988699763 @default.
- W2065140692 cites W1990595453 @default.
- W2065140692 cites W1995235992 @default.
- W2065140692 cites W1995689817 @default.
- W2065140692 cites W1997664110 @default.
- W2065140692 cites W1998826717 @default.
- W2065140692 cites W2002613500 @default.
- W2065140692 cites W2006296875 @default.
- W2065140692 cites W2008485465 @default.
- W2065140692 cites W2008721781 @default.
- W2065140692 cites W2010824032 @default.
- W2065140692 cites W2011952176 @default.
- W2065140692 cites W2012941860 @default.
- W2065140692 cites W2014927326 @default.
- W2065140692 cites W2015163544 @default.
- W2065140692 cites W2015433283 @default.
- W2065140692 cites W2017380383 @default.
- W2065140692 cites W2018526785 @default.
- W2065140692 cites W2024662539 @default.
- W2065140692 cites W2024854434 @default.
- W2065140692 cites W2027249320 @default.
- W2065140692 cites W2029735140 @default.
- W2065140692 cites W2029918311 @default.
- W2065140692 cites W2032997521 @default.
- W2065140692 cites W2034744996 @default.
- W2065140692 cites W2035666161 @default.
- W2065140692 cites W2039422203 @default.
- W2065140692 cites W2040056237 @default.
- W2065140692 cites W2043285008 @default.
- W2065140692 cites W2046477557 @default.
- W2065140692 cites W2050001093 @default.
- W2065140692 cites W2054658934 @default.
- W2065140692 cites W2054878669 @default.
- W2065140692 cites W2055762446 @default.
- W2065140692 cites W2060719924 @default.
- W2065140692 cites W2060762906 @default.
- W2065140692 cites W2061959498 @default.
- W2065140692 cites W2062219794 @default.
- W2065140692 cites W2065045903 @default.
- W2065140692 cites W2065656296 @default.
- W2065140692 cites W2067520762 @default.
- W2065140692 cites W2068271949 @default.
- W2065140692 cites W2071467059 @default.
- W2065140692 cites W2071675524 @default.
- W2065140692 cites W2072255769 @default.
- W2065140692 cites W2072942230 @default.
- W2065140692 cites W2082955274 @default.
- W2065140692 cites W2086836718 @default.
- W2065140692 cites W2090336391 @default.
- W2065140692 cites W2091740604 @default.
- W2065140692 cites W2092120184 @default.
- W2065140692 cites W2094780751 @default.
- W2065140692 cites W2095635162 @default.
- W2065140692 cites W2098128155 @default.
- W2065140692 cites W2113070086 @default.
- W2065140692 cites W2113805681 @default.
- W2065140692 cites W2124706727 @default.
- W2065140692 cites W2128496740 @default.
- W2065140692 cites W2128647604 @default.
- W2065140692 cites W2129771435 @default.
- W2065140692 cites W2129963319 @default.
- W2065140692 cites W2130553995 @default.
- W2065140692 cites W2132864917 @default.
- W2065140692 cites W2135577920 @default.
- W2065140692 cites W2139584581 @default.
- W2065140692 cites W2142287897 @default.