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• W2065142203 abstract "Francisella tularensis subsp. tularensis is classified as a Category A bioweapon that is capable of establishing a lethal infection in humans upon inhalation of very few organisms. However, the virulence mechanisms of this organism are not well characterized. Francisella tularensis subsp. novicida, which is an equally virulent subspecies in mice, was used in concert with a microPET scanner to better understand its temporal dissemination in vivo upon intranasal infection and how such dissemination compares with other routes of infection. Adult mice were inoculated intranasally with F. tularensis subsp. novicida radiolabeled with 64Cu and imaged by microPET at 0.25, 2 and 20 hours post-infection.64Cu labeled F. tularensis subsp. novicida administered intranasally or intratracheally were visualized in the respiratory tract and stomach at 0.25 hours post infection. By 20 hours, there was significant tropism to the lung compared with other tissues. In contrast, the images of radiolabeled F. tularensis subsp. novicida when administered intragastrically, intradermally, intraperitoneally and intravenouslly were more generally limited to the gastrointestinal system, site of inoculation, liver and spleen respectively. MicroPET images correlated with the biodistribution of isotope and bacterial burdens in analyzed tissues.Our findings suggest that Francisella has a differential tissue tropism depending on the route of entry and that the virulence of Francisella by the pulmonary route is associated with a rapid bacteremia and an early preferential tropism to the lung. In addition, the use of the microPET device allowed us to identify the cecum as a novel site of colonization of Francisella tularensis subsp. novicida in mice." @default.
• W2065142203 created "2016-06-24" @default.
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• W2065142203 date "2008-12-01" @default.
• W2065142203 modified "2023-10-16" @default.
• W2065142203 title "Rapid dissemination of Francisella tularensisand the effect of route of infection" @default.
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• W2065142203 doi "https://doi.org/10.1186/1471-2180-8-215" @default.
• W2065142203 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2651876" @default.
• W2065142203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19068128" @default.
• W2065142203 hasPublicationYear "2008" @default.
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