Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065144515> ?p ?o ?g. }
- W2065144515 endingPage "749" @default.
- W2065144515 startingPage "739" @default.
- W2065144515 abstract "Kinins modulate renal function, yet their role in the developing kidney is largely unknown. To explore the developmental role of the kallikrein-kinin system, we examined the postnatal ontogeny and intrarenal localization of B2 receptors in the rat. Northern blot analysis and RT-PCR documented the expression of B2 receptor mRNA in the kidney and extrarenal tissues of fetal, neonatal and adult animals. The abundance of B2 receptor mRNA is 10- to 30-fold higher in neonatal than adult tissues in the following order: kidney > heart > aorta > lung > brain. Receptor autoradiography revealed a gradual shift in the localization of bradykinin binding sites from the outer cortex in the newborn to the outer medulla in weanling and maturing rats. The almost complete displacement of [125I]tyr(zero)-bradykinin by HOE-140 indicates that the majority of kinin receptors in the developing kidney belong to the B2 type. Immunolocalization studies using antipeptide antibodies directed against various portions of the receptor revealed that B2 receptors are first expressed on the luminal aspect of the upper limb of S-shaped bodies and differentiating cortical collecting ducts. In marked contrast, the metanephric mesenchyme, pretubular aggregates and glomeruli display weak or no B2 receptor immunoreactivity. Following completion of nephrogenesis, B2 receptor expression shifts to both luminal and basolateral aspects of connecting tubules and collecting ducts. The results demonstrate that bradykinin B2 receptor gene expression is activated in the developing kidney and cardiovascular system. The spatially restricted expression of B2 receptors in the differentiating epithelium of the distal nephron, the site of kinin formation, supports the hypothesis that kinins are paracrine modulators of segmental nephron maturation." @default.
- W2065144515 created "2016-06-24" @default.
- W2065144515 creator A5037408048 @default.
- W2065144515 creator A5044765791 @default.
- W2065144515 creator A5066616713 @default.
- W2065144515 creator A5075814041 @default.
- W2065144515 date "1997-03-01" @default.
- W2065144515 modified "2023-10-16" @default.
- W2065144515 title "Ontogeny of bradykinin B2 receptors in the rat kidney: Implications for segmental nephron maturation" @default.
- W2065144515 cites W1499995013 @default.
- W2065144515 cites W1554136003 @default.
- W2065144515 cites W1928479069 @default.
- W2065144515 cites W1978574452 @default.
- W2065144515 cites W1987637136 @default.
- W2065144515 cites W1988618219 @default.
- W2065144515 cites W1997261857 @default.
- W2065144515 cites W2002731861 @default.
- W2065144515 cites W2005889776 @default.
- W2065144515 cites W2013813492 @default.
- W2065144515 cites W2017603054 @default.
- W2065144515 cites W2023101179 @default.
- W2065144515 cites W2025003289 @default.
- W2065144515 cites W2025540579 @default.
- W2065144515 cites W2032552530 @default.
- W2065144515 cites W2036734539 @default.
- W2065144515 cites W2051674444 @default.
- W2065144515 cites W2053596207 @default.
- W2065144515 cites W2053944765 @default.
- W2065144515 cites W2062964643 @default.
- W2065144515 cites W2063301557 @default.
- W2065144515 cites W2065137629 @default.
- W2065144515 cites W2067349865 @default.
- W2065144515 cites W2077313364 @default.
- W2065144515 cites W2114881859 @default.
- W2065144515 cites W2134958970 @default.
- W2065144515 cites W2164620775 @default.
- W2065144515 cites W2255150349 @default.
- W2065144515 cites W4294216491 @default.
- W2065144515 doi "https://doi.org/10.1038/ki.1997.105" @default.
- W2065144515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9067906" @default.
- W2065144515 hasPublicationYear "1997" @default.
- W2065144515 type Work @default.
- W2065144515 sameAs 2065144515 @default.
- W2065144515 citedByCount "62" @default.
- W2065144515 countsByYear W20651445152012 @default.
- W2065144515 countsByYear W20651445152013 @default.
- W2065144515 countsByYear W20651445152016 @default.
- W2065144515 countsByYear W20651445152017 @default.
- W2065144515 countsByYear W20651445152018 @default.
- W2065144515 countsByYear W20651445152019 @default.
- W2065144515 countsByYear W20651445152020 @default.
- W2065144515 countsByYear W20651445152022 @default.
- W2065144515 countsByYear W20651445152023 @default.
- W2065144515 crossrefType "journal-article" @default.
- W2065144515 hasAuthorship W2065144515A5037408048 @default.
- W2065144515 hasAuthorship W2065144515A5044765791 @default.
- W2065144515 hasAuthorship W2065144515A5066616713 @default.
- W2065144515 hasAuthorship W2065144515A5075814041 @default.
- W2065144515 hasBestOaLocation W20651445151 @default.
- W2065144515 hasConcept C104317684 @default.
- W2065144515 hasConcept C126322002 @default.
- W2065144515 hasConcept C134018914 @default.
- W2065144515 hasConcept C150194340 @default.
- W2065144515 hasConcept C153939273 @default.
- W2065144515 hasConcept C170493617 @default.
- W2065144515 hasConcept C17291353 @default.
- W2065144515 hasConcept C196843134 @default.
- W2065144515 hasConcept C2776246183 @default.
- W2065144515 hasConcept C2776340970 @default.
- W2065144515 hasConcept C2779591629 @default.
- W2065144515 hasConcept C2780091579 @default.
- W2065144515 hasConcept C2781231759 @default.
- W2065144515 hasConcept C55493867 @default.
- W2065144515 hasConcept C71924100 @default.
- W2065144515 hasConcept C81439078 @default.
- W2065144515 hasConcept C86803240 @default.
- W2065144515 hasConcept C95444343 @default.
- W2065144515 hasConceptScore W2065144515C104317684 @default.
- W2065144515 hasConceptScore W2065144515C126322002 @default.
- W2065144515 hasConceptScore W2065144515C134018914 @default.
- W2065144515 hasConceptScore W2065144515C150194340 @default.
- W2065144515 hasConceptScore W2065144515C153939273 @default.
- W2065144515 hasConceptScore W2065144515C170493617 @default.
- W2065144515 hasConceptScore W2065144515C17291353 @default.
- W2065144515 hasConceptScore W2065144515C196843134 @default.
- W2065144515 hasConceptScore W2065144515C2776246183 @default.
- W2065144515 hasConceptScore W2065144515C2776340970 @default.
- W2065144515 hasConceptScore W2065144515C2779591629 @default.
- W2065144515 hasConceptScore W2065144515C2780091579 @default.
- W2065144515 hasConceptScore W2065144515C2781231759 @default.
- W2065144515 hasConceptScore W2065144515C55493867 @default.
- W2065144515 hasConceptScore W2065144515C71924100 @default.
- W2065144515 hasConceptScore W2065144515C81439078 @default.
- W2065144515 hasConceptScore W2065144515C86803240 @default.
- W2065144515 hasConceptScore W2065144515C95444343 @default.
- W2065144515 hasIssue "3" @default.
- W2065144515 hasLocation W20651445151 @default.
- W2065144515 hasLocation W20651445152 @default.