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- W2065154991 abstract "Background: The IL-1β exon5 (+3954) has been related to the pathogenesis of lupus, but the role of IL-1 polymorphisms in the aetiology of systemic lupus erythematosus (SLE) is unknown.Method: We compare the IL-1 beta +3954 (exon5) gene polymorphism among 52 SLE patients and healthy controls in north-eastern Iran. Polymorphism of the gene for IL-1 beta +3954 was typed after the genomic DNA was amplified by polymerase chain reaction-sequence-specific-primers technique.Results: Comparing the results show no significant differences in the frequency of IL-1 beta exon5 allels between patients with SLE and controls. Additionally, we did not detect any association of IL-1 beta exon5 (+3954) genotype with clinical and laboratory profiles in SLE patients.Conclusion: The polymorphism of the IL-1 beta exon5 allele is not associated with genetic susceptibility to SLE in north-eastern of Iran." @default.
- W2065154991 created "2016-06-24" @default.
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- W2065154991 date "2008-04-01" @default.
- W2065154991 modified "2023-09-26" @default.
- W2065154991 title "Association of IL-1 beta gene polymorphism with susceptibility to systemic lupus erythematosus" @default.
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- W2065154991 doi "https://doi.org/10.1111/j.1756-185x.2008.00326.x" @default.
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