FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065156731> ?p ?o ?g. }

• W2065156731 endingPage "R1384" @default.
• W2065156731 startingPage "R1376" @default.
• W2065156731 abstract "We investigated the levels of adrenomedullin (AM) system during the process of preadipocyte differentiation and its role in lipid metabolism and cellular signaling mechanism in differentiated adipocytes. We cultured rat preadipocytes and measured the following during the process of differentiation: two molecular forms of AM in the culture medium using a specific immunoradiometric assay and gene expression of AM and its receptor component using RT-PCR analysis. In differentiated adipocytes, we measured the effects of AM on the intracellular cAMP level, lipolysis, glucose incorporation, and the protein levels. Two molecular forms of AM were secreted into the medium, and the AM-mature/AM-total ratio was increased after 6 days of differentiation. Cultured rat preadipocytes highly expressed the genes of AM and its receptor components at day 1, and they increased at day 10. Administration of AM to preadipocytes increased the number of Oil Red O-positive adipocytes and spectrophotometric absorbance of Oil Red O. AM dose dependently increased cAMP level and lipolysis, and its effect was blocked by CGRP(8-37). Isoproterenol increased lipolysis, and AM had additive effects on isoproterenol-induced lipolysis. KT5720 and U0126 significantly inhibited the AM-induced lipolysis, whereas KT5720, but not U0126, significantly inhibited the isoproterenol-induced lipolysis. AM increased glucose incorporation and its effect was blocked by wortmannin. Western blot analysis revealed that AM increased phospho PKA, ERK, and Akt. These results indicate that AM and its receptor component are highly expressed in cultured adipocytes and may play a role in lipid metabolism via a different signaling pathway." @default.
• W2065156731 created "2016-06-24" @default.
• W2065156731 creator A5019181436 @default.
• W2065156731 creator A5023178862 @default.
• W2065156731 creator A5028636839 @default.
• W2065156731 creator A5057681787 @default.
• W2065156731 creator A5058761966 @default.
• W2065156731 creator A5070910498 @default.
• W2065156731 date "2008-11-01" @default.
• W2065156731 modified "2023-09-24" @default.
• W2065156731 title "Role of adrenomedullin system in lipid metabolism and its signaling mechanism in cultured adipocytes" @default.
• W2065156731 cites W1972441205 @default.
• W2065156731 cites W1974560613 @default.
• W2065156731 cites W1981986824 @default.
• W2065156731 cites W1987183678 @default.
• W2065156731 cites W1992816049 @default.
• W2065156731 cites W2015149522 @default.
• W2065156731 cites W2020549088 @default.
• W2065156731 cites W2028625021 @default.
• W2065156731 cites W2029260226 @default.
• W2065156731 cites W2037386031 @default.
• W2065156731 cites W2038563834 @default.
• W2065156731 cites W2041335773 @default.
• W2065156731 cites W2051372947 @default.
• W2065156731 cites W2051587975 @default.
• W2065156731 cites W2061079006 @default.
• W2065156731 cites W2062692217 @default.
• W2065156731 cites W2067801294 @default.
• W2065156731 cites W2068727683 @default.
• W2065156731 cites W2070125125 @default.
• W2065156731 cites W2073796511 @default.
• W2065156731 cites W2087349962 @default.
• W2065156731 cites W2087697259 @default.
• W2065156731 cites W2091734598 @default.
• W2065156731 cites W2092419989 @default.
• W2065156731 cites W2095626453 @default.
• W2065156731 cites W2098455918 @default.
• W2065156731 cites W2111112233 @default.
• W2065156731 cites W2116445223 @default.
• W2065156731 cites W2120774702 @default.
• W2065156731 cites W2127985487 @default.
• W2065156731 cites W2130531231 @default.
• W2065156731 cites W2138340694 @default.
• W2065156731 cites W2146664412 @default.
• W2065156731 cites W2152948578 @default.
• W2065156731 cites W2186076234 @default.
• W2065156731 cites W2312246671 @default.
• W2065156731 cites W2323358865 @default.
• W2065156731 cites W337045251 @default.
• W2065156731 doi "https://doi.org/10.1152/ajpregu.90467.2008" @default.
• W2065156731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18685068" @default.
• W2065156731 hasPublicationYear "2008" @default.
• W2065156731 type Work @default.
• W2065156731 sameAs 2065156731 @default.
• W2065156731 citedByCount "25" @default.
• W2065156731 countsByYear W20651567312012 @default.
• W2065156731 countsByYear W20651567312013 @default.
• W2065156731 countsByYear W20651567312014 @default.
• W2065156731 countsByYear W20651567312015 @default.
• W2065156731 countsByYear W20651567312016 @default.
• W2065156731 countsByYear W20651567312017 @default.
• W2065156731 countsByYear W20651567312019 @default.
• W2065156731 countsByYear W20651567312020 @default.
• W2065156731 countsByYear W20651567312021 @default.
• W2065156731 crossrefType "journal-article" @default.
• W2065156731 hasAuthorship W2065156731A5019181436 @default.
• W2065156731 hasAuthorship W2065156731A5023178862 @default.
• W2065156731 hasAuthorship W2065156731A5028636839 @default.
• W2065156731 hasAuthorship W2065156731A5057681787 @default.
• W2065156731 hasAuthorship W2065156731A5058761966 @default.
• W2065156731 hasAuthorship W2065156731A5070910498 @default.
• W2065156731 hasConcept C126322002 @default.
• W2065156731 hasConcept C134018914 @default.
• W2065156731 hasConcept C140985366 @default.
• W2065156731 hasConcept C170493617 @default.
• W2065156731 hasConcept C171089720 @default.
• W2065156731 hasConcept C185592680 @default.
• W2065156731 hasConcept C25095133 @default.
• W2065156731 hasConcept C2776175234 @default.
• W2065156731 hasConcept C2777152744 @default.
• W2065156731 hasConcept C2778308172 @default.
• W2065156731 hasConcept C4733338 @default.
• W2065156731 hasConcept C55493867 @default.
• W2065156731 hasConcept C57074206 @default.
• W2065156731 hasConcept C62478195 @default.
• W2065156731 hasConcept C71924100 @default.
• W2065156731 hasConcept C75217442 @default.
• W2065156731 hasConcept C86803240 @default.
• W2065156731 hasConceptScore W2065156731C126322002 @default.
• W2065156731 hasConceptScore W2065156731C134018914 @default.
• W2065156731 hasConceptScore W2065156731C140985366 @default.
• W2065156731 hasConceptScore W2065156731C170493617 @default.
• W2065156731 hasConceptScore W2065156731C171089720 @default.
• W2065156731 hasConceptScore W2065156731C185592680 @default.
• W2065156731 hasConceptScore W2065156731C25095133 @default.
• W2065156731 hasConceptScore W2065156731C2776175234 @default.
• W2065156731 hasConceptScore W2065156731C2777152744 @default.
• W2065156731 hasConceptScore W2065156731C2778308172 @default.

• next