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- W2065162561 abstract "Abstract Comparison of the three‐dimensional structures of native endothiapepsin (EC 3.4.23.6) and 15 endothiapepsin oligopeptide inhibitor complexes defined at high resolution by X‐ray crystallography shows that endothiapepsin exists in two forms differing in the relative orientation of a domain comprising residues 190–302. There are relatively few interactions between the two parts of the enzyme; consequently, they can move as separate rigid bodies. A translational, librational, and screw analysis of the thermal parameters of endothiapepsin also supports and model in which the two parts can move relative to each other. In the comparison of different aspartic proteinases, the rms values are reduced by up to 47% when the two parts of the structure are superposed independently. This justifies description of the differences, including those between pepsinogen and pepsin (EC 3.4.34.1), as a rigid movement of one part relative to another although considerable distortions within the domains also occur. The consequence of the rigid body movement is a change in the shape of the active site cleft that is largest around the S 3 pocket. This is associated with a different position and conformation of the inhibitors that are bound to the two endothiapepsin forms. The relevance of these observations to a model of the hydrolysis by aspartic proteinases is briefly discussed." @default.
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- W2065162561 date "1992-02-01" @default.
- W2065162561 modified "2023-10-18" @default.
- W2065162561 title "Domain flexibility in aspartic proteinases" @default.
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- W2065162561 doi "https://doi.org/10.1002/prot.340120209" @default.
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