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- W2065162906 abstract "Thirty-nine steroids were investigated with respect to their ability to compete with 3H-testosterone for binding-sites on the sex hormone-binding globulin of late pregnancy human plasma. Results were compared using plasma diluted to 0.5% with water and with phosphate buffer. Florisil was used to adsorb unbound steroid. Under these conditions the observed binding of 3H-testosterone to plasma was greater in water than in phosphate buffer. The competition of each steroid was assessed against that of testosterone. Addition of methyl groups at the C-7, or C-17α positions or the addition of an ethinyl group at C-17α tended to decrease binding as did unsaturation at C-1 and C-6. Most 19-nor compounds had only about 10% of the binding activity of the parent compound. However androst-5-ene-3β, 17β-diol was bound less strongly than its 19-nor analog, estr-5-ene-3β,17β-diol which was more than twice as active as testosterone itself. Results using water and phosphate buffer differed slightly but significantly for 3 compounds, all of which contained the estr-5-en-17β-ol structure." @default.
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- W2065162906 title "Further studies of the specificity of the sex hormone-binding globulin of human plasma" @default.
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- W2065162906 doi "https://doi.org/10.1016/s0039-128x(70)80155-6" @default.
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