FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065164053> ?p ?o ?g. }

• W2065164053 abstract "In a recent study of focal cerebral ischemia in rats, pre-ischemic administration of the synthetic allosteric hemoglobin modifier RSR13 (2-[4-[[3,5-dimethylanilino) carbonyl] methyl] phenoxy]-2-methylproprionic acid) reduced cerebral infarct size when combined with the NMDA receptor antagonist dizocilpine (MK-801) but not when given alone. We hypothesized that post-ischemic RSR13 administration would enhance neuroprotection afforded by NMDA receptor antagonism in a rat model of transient middle cerebral artery occlusion (MCAO). Fasted normothermic Wistar rats underwent 75 min of temporary MCAO. At onset of reperfusion, rats randomly received: (1) 0.9% NaCl (vehicle) i.v. alone (n=16); (2) 0.9% NaCl+dizocilpine (0.25 mg/kg) i.v. (n=16); or (3) RSR13 (150 mg/kg)+dizocilpine (0.25 mg/kg) i.v. (n=17). Seven days later, neurologic deficit and cerebral infarct size were determined. Dizocilpine alone compared to vehicle reduced mean+/-S.D. subcortical (52+/-24 mm(3) vs. 122+/-64 mm(3), P=0.003) and cortical (35+/-35 mm(3) vs. 125+/-72 mm(3), P=0.00074) infarct volumes. When compared to dizocilpine alone, the combination of RSR13+dizocilpine further reduced subcortical (37+/-14 mm(3) vs. 52+/-24 mm(3), P=0. 034) and cortical (8+/-19 mm(3) vs. 35+/-35 mm(3), P=0.018) infarct size. RSR13+dizocilpine improved neurologic scores vs. either dizocilpine alone (P=0.0014) or vehicle (P=10(-7)). The combination of NMDA receptor antagonism and a RSR13 mediated rightward shift of the oxy-hemoglobin dissociation curve improved outcome from MCAO. Because this occurred after reperfusion, our results suggest that the post-ischemic brain continues to suffer from hypoperfusion defects, which are amenable to therapy by enhanced O(2) delivery. The results also support the concept that neuroprotective strategies, which combine drugs with different mechanisms of action, may yield cumulative benefits." @default.
• W2065164053 created "2016-06-24" @default.
• W2065164053 creator A5015901694 @default.
• W2065164053 creator A5025813719 @default.
• W2065164053 creator A5050506489 @default.
• W2065164053 creator A5053373507 @default.
• W2065164053 creator A5053490576 @default.
• W2065164053 creator A5070444978 @default.
• W2065164053 creator A5070493365 @default.
• W2065164053 date "2000-01-01" @default.
• W2065164053 modified "2023-09-26" @default.
• W2065164053 title "Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat" @default.
• W2065164053 cites W1492123500 @default.
• W2065164053 cites W1633517302 @default.
• W2065164053 cites W1889743606 @default.
• W2065164053 cites W1964951686 @default.
• W2065164053 cites W1970427487 @default.
• W2065164053 cites W1971205444 @default.
• W2065164053 cites W1974135000 @default.
• W2065164053 cites W1978428462 @default.
• W2065164053 cites W1985394468 @default.
• W2065164053 cites W1991381764 @default.
• W2065164053 cites W2004636083 @default.
• W2065164053 cites W2005733541 @default.
• W2065164053 cites W2013900800 @default.
• W2065164053 cites W2033240573 @default.
• W2065164053 cites W2034054809 @default.
• W2065164053 cites W2035838366 @default.
• W2065164053 cites W2046297960 @default.
• W2065164053 cites W2051455813 @default.
• W2065164053 cites W2054227747 @default.
• W2065164053 cites W2071396639 @default.
• W2065164053 cites W2077484357 @default.
• W2065164053 cites W2078098282 @default.
• W2065164053 cites W2079609158 @default.
• W2065164053 cites W2108501697 @default.
• W2065164053 cites W2112505121 @default.
• W2065164053 cites W2112763282 @default.
• W2065164053 cites W2129648625 @default.
• W2065164053 cites W2132370926 @default.
• W2065164053 cites W2134404886 @default.
• W2065164053 cites W2146638685 @default.
• W2065164053 cites W2150259338 @default.
• W2065164053 cites W2157645771 @default.
• W2065164053 cites W2218164610 @default.
• W2065164053 cites W2317320087 @default.
• W2065164053 cites W2320546708 @default.
• W2065164053 cites W2410787921 @default.
• W2065164053 doi "https://doi.org/10.1016/s0006-8993(99)02212-x" @default.
• W2065164053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10627303" @default.
• W2065164053 hasPublicationYear "2000" @default.
• W2065164053 type Work @default.
• W2065164053 sameAs 2065164053 @default.
• W2065164053 citedByCount "8" @default.
• W2065164053 countsByYear W20651640532019 @default.
• W2065164053 crossrefType "journal-article" @default.
• W2065164053 hasAuthorship W2065164053A5015901694 @default.
• W2065164053 hasAuthorship W2065164053A5025813719 @default.
• W2065164053 hasAuthorship W2065164053A5050506489 @default.
• W2065164053 hasAuthorship W2065164053A5053373507 @default.
• W2065164053 hasAuthorship W2065164053A5053490576 @default.
• W2065164053 hasAuthorship W2065164053A5070444978 @default.
• W2065164053 hasAuthorship W2065164053A5070493365 @default.
• W2065164053 hasConcept C126322002 @default.
• W2065164053 hasConcept C170493617 @default.
• W2065164053 hasConcept C25498285 @default.
• W2065164053 hasConcept C2776885963 @default.
• W2065164053 hasConcept C2777836312 @default.
• W2065164053 hasConcept C42219234 @default.
• W2065164053 hasConcept C541997718 @default.
• W2065164053 hasConcept C67018056 @default.
• W2065164053 hasConcept C71924100 @default.
• W2065164053 hasConcept C98274493 @default.
• W2065164053 hasConceptScore W2065164053C126322002 @default.
• W2065164053 hasConceptScore W2065164053C170493617 @default.
• W2065164053 hasConceptScore W2065164053C25498285 @default.
• W2065164053 hasConceptScore W2065164053C2776885963 @default.
• W2065164053 hasConceptScore W2065164053C2777836312 @default.
• W2065164053 hasConceptScore W2065164053C42219234 @default.
• W2065164053 hasConceptScore W2065164053C541997718 @default.
• W2065164053 hasConceptScore W2065164053C67018056 @default.
• W2065164053 hasConceptScore W2065164053C71924100 @default.
• W2065164053 hasConceptScore W2065164053C98274493 @default.
• W2065164053 hasLocation W20651640531 @default.
• W2065164053 hasLocation W20651640532 @default.
• W2065164053 hasOpenAccess W2065164053 @default.
• W2065164053 hasPrimaryLocation W20651640531 @default.
• W2065164053 hasRelatedWork W1985394468 @default.
• W2065164053 hasRelatedWork W1988218290 @default.
• W2065164053 hasRelatedWork W1991629492 @default.
• W2065164053 hasRelatedWork W2010247158 @default.
• W2065164053 hasRelatedWork W2011841319 @default.
• W2065164053 hasRelatedWork W2027211823 @default.
• W2065164053 hasRelatedWork W2034614276 @default.
• W2065164053 hasRelatedWork W2035943184 @default.
• W2065164053 hasRelatedWork W2044839361 @default.
• W2065164053 hasRelatedWork W2045563360 @default.
• W2065164053 hasRelatedWork W2046902224 @default.
• W2065164053 hasRelatedWork W2056209103 @default.
• W2065164053 hasRelatedWork W2062796704 @default.

• next