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- W2065164093 abstract "During T cell development, the processes of selection and tolerance act on the universe of expressed T cell receptors in the thymic cortex to form the repertoire of mature T cells that will respond to foreign antigen in the context of self-MHC in that animal. We have subdivided the cortical thymocytes into three functionally distinct populations: one population which is antigen-receptor negative, a second population which is antigen-receptor positive and is resistant to deletion by signaling through the antigen receptor, and a third population which is also antigen-receptor positive but is sensitive to deletion. These results have implications for the cellular compartments in which positive and negative selection occur and for the biochemical mechanisms that mediate selection and tolerance." @default.
- W2065164093 created "2016-06-24" @default.
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- W2065164093 date "1989-09-22" @default.
- W2065164093 modified "2023-09-23" @default.
- W2065164093 title "The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR" @default.
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- W2065164093 doi "https://doi.org/10.1016/0092-8674(89)90503-5" @default.
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