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• W2065168340 abstract "A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing spontaneous and induced ventricular tachycardia; this is a major step towards clinical adoption of cell replacement therapies for cardiovascular diseases using human cardiomyocytes. This study extends previous findings that transplantation of fetal cardiomyocytes can improve the function of infarcted hearts, despite having only a modest effect on the organ's mechanical properties. The investigators developed a guinea pig model of cardiac injury, because the heart rate of these animals is at the upper end of what is tolerable to human cardiomyocytes, and much lower than that of the mice and rats often used as models. The authors show that cardiomyocytes derived from human embryonic stem cells can integrate electrically into the guinea pig heart and protect against arrhythmias. This is the first convincing evidence that cardiomyocytes generated from cultured human embryonic stem cells can integrate into the adult heart, and is therefore a major step towards the clinical adoption of cell-replacement therapies for cardiovascular disease. Transplantation studies in mice and rats have shown that human embryonic-stem-cell-derived cardiomyocytes (hESC-CMs) can improve the function of infarcted hearts1,2,3, but two critical issues related to their electrophysiological behaviour in vivo remain unresolved. First, the risk of arrhythmias following hESC-CM transplantation in injured hearts has not been determined. Second, the electromechanical integration of hESC-CMs in injured hearts has not been demonstrated, so it is unclear whether these cells improve contractile function directly through addition of new force-generating units. Here we use a guinea-pig model to show that hESC-CM grafts in injured hearts protect against arrhythmias and can contract synchronously with host muscle. Injured hearts with hESC-CM grafts show improved mechanical function and a significantly reduced incidence of both spontaneous and induced ventricular tachycardia. To assess the activity of hESC-CM grafts in vivo, we transplanted hESC-CMs expressing the genetically encoded calcium sensor, GCaMP3 (refs 4, 5). By correlating the GCaMP3 fluorescent signal with the host ECG, we found that grafts in uninjured hearts have consistent 1:1 host–graft coupling. Grafts in injured hearts are more heterogeneous and typically include both coupled and uncoupled regions. Thus, human myocardial grafts meet physiological criteria for true heart regeneration, providing support for the continued development of hESC-based cardiac therapies for both mechanical and electrical repair." @default.
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• W2065168340 date "2012-08-05" @default.
• W2065168340 modified "2023-10-02" @default.
• W2065168340 title "Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts" @default.
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• W2065168340 doi "https://doi.org/10.1038/nature11317" @default.
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