FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065176781> ?p ?o ?g. }

• W2065176781 abstract "The identification of circulating tumour cells (CTCs) in peripheral blood is a useful approach to estimate prognosis, monitor disease progression, and measure treatment effects in various malignancies. However, clinical relevance of CTCs is controversial. We attempted to detect viable CTCs in the peripheral blood of gastric cancer patients using a telomerase-specific viral agent. We took a 7.5-ml blood sample from 65 treatment-negative gastric cancer patients before surgery and 10 healthy volunteers. We detected viable CTCs in the blood samples after incubating them with a telomerase-specific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein (GFP) gene (OBP-401). GFP-positive CTCs were defined as having a diameter of at least 7.735 μm; this threshold was determined by receiver operating characteristic curve analysis. GFP-positive cells were counted under a fluorescence microscope. There was a significant difference in overall survival among the patients with 0–4 and those with ≥5 GFP-positive CTCs in the stage I–IV disease group and stage II–IV advanced disease group. The number of GFP-positive CTCs was not related to cancer stage. Among the pathological findings, the number of GFP-positive CTCs was only significantly related to venous invasion, although there were trends towards more GFP-positive CTCs with disease progression (tumour depth, lymph node metastasis, distant metastasis, lymphatic invasion, and histological type). There was a significant relationship between the number of GFP-positive CTCs and overall survival in the patients with gastric cancer. The detection of CTCs using OBP-401 may be useful for prognostic evaluation. University Hospital Medical Information Network in Japan, UMIN000002018." @default.
• W2065176781 created "2016-06-24" @default.
• W2065176781 creator A5004361618 @default.
• W2065176781 creator A5009468301 @default.
• W2065176781 creator A5015454789 @default.
• W2065176781 creator A5019377326 @default.
• W2065176781 creator A5023483339 @default.
• W2065176781 creator A5028238865 @default.
• W2065176781 creator A5043631647 @default.
• W2065176781 creator A5049171723 @default.
• W2065176781 creator A5051119293 @default.
• W2065176781 creator A5056761543 @default.
• W2065176781 creator A5064388156 @default.
• W2065176781 date "2012-08-09" @default.
• W2065176781 modified "2023-10-16" @default.
• W2065176781 title "Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study" @default.
• W2065176781 cites W1558034062 @default.
• W2065176781 cites W1579661837 @default.
• W2065176781 cites W1967625972 @default.
• W2065176781 cites W1974950800 @default.
• W2065176781 cites W1990120645 @default.
• W2065176781 cites W199647299 @default.
• W2065176781 cites W2000971601 @default.
• W2065176781 cites W2003143414 @default.
• W2065176781 cites W2003533730 @default.
• W2065176781 cites W2014941146 @default.
• W2065176781 cites W2017495608 @default.
• W2065176781 cites W2023966374 @default.
• W2065176781 cites W2034269086 @default.
• W2065176781 cites W2050547995 @default.
• W2065176781 cites W2051227781 @default.
• W2065176781 cites W2053961194 @default.
• W2065176781 cites W2074223747 @default.
• W2065176781 cites W2076668534 @default.
• W2065176781 cites W2077023431 @default.
• W2065176781 cites W2081979270 @default.
• W2065176781 cites W2085277301 @default.
• W2065176781 cites W2086026198 @default.
• W2065176781 cites W2108816382 @default.
• W2065176781 cites W2111976640 @default.
• W2065176781 cites W2116388783 @default.
• W2065176781 cites W2118775408 @default.
• W2065176781 cites W2126236874 @default.
• W2065176781 cites W2126822099 @default.
• W2065176781 cites W2135674966 @default.
• W2065176781 cites W2144584725 @default.
• W2065176781 cites W2148703808 @default.
• W2065176781 cites W2153557899 @default.
• W2065176781 cites W2170755208 @default.
• W2065176781 doi "https://doi.org/10.1186/1471-2407-12-346" @default.
• W2065176781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3495032" @default.
• W2065176781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22873704" @default.
• W2065176781 hasPublicationYear "2012" @default.
• W2065176781 type Work @default.
• W2065176781 sameAs 2065176781 @default.
• W2065176781 citedByCount "34" @default.
• W2065176781 countsByYear W20651767812013 @default.
• W2065176781 countsByYear W20651767812014 @default.
• W2065176781 countsByYear W20651767812015 @default.
• W2065176781 countsByYear W20651767812016 @default.
• W2065176781 countsByYear W20651767812017 @default.
• W2065176781 countsByYear W20651767812018 @default.
• W2065176781 countsByYear W20651767812019 @default.
• W2065176781 countsByYear W20651767812020 @default.
• W2065176781 countsByYear W20651767812022 @default.
• W2065176781 countsByYear W20651767812023 @default.
• W2065176781 crossrefType "journal-article" @default.
• W2065176781 hasAuthorship W2065176781A5004361618 @default.
• W2065176781 hasAuthorship W2065176781A5009468301 @default.
• W2065176781 hasAuthorship W2065176781A5015454789 @default.
• W2065176781 hasAuthorship W2065176781A5019377326 @default.
• W2065176781 hasAuthorship W2065176781A5023483339 @default.
• W2065176781 hasAuthorship W2065176781A5028238865 @default.
• W2065176781 hasAuthorship W2065176781A5043631647 @default.
• W2065176781 hasAuthorship W2065176781A5049171723 @default.
• W2065176781 hasAuthorship W2065176781A5051119293 @default.
• W2065176781 hasAuthorship W2065176781A5056761543 @default.
• W2065176781 hasAuthorship W2065176781A5064388156 @default.
• W2065176781 hasBestOaLocation W20651767811 @default.
• W2065176781 hasConcept C104317684 @default.
• W2065176781 hasConcept C121608353 @default.
• W2065176781 hasConcept C126322002 @default.
• W2065176781 hasConcept C142613039 @default.
• W2065176781 hasConcept C142724271 @default.
• W2065176781 hasConcept C143998085 @default.
• W2065176781 hasConcept C146357865 @default.
• W2065176781 hasConcept C151730666 @default.
• W2065176781 hasConcept C2778123414 @default.
• W2065176781 hasConcept C2779013556 @default.
• W2065176781 hasConcept C2779529041 @default.
• W2065176781 hasConcept C2780140570 @default.
• W2065176781 hasConcept C502942594 @default.
• W2065176781 hasConcept C55493867 @default.
• W2065176781 hasConcept C61238886 @default.
• W2065176781 hasConcept C71924100 @default.
• W2065176781 hasConcept C86803240 @default.
• W2065176781 hasConcept C94581717 @default.
• W2065176781 hasConcept C96232424 @default.
• W2065176781 hasConceptScore W2065176781C104317684 @default.
• W2065176781 hasConceptScore W2065176781C121608353 @default.

• next