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- W2065183886 abstract "Legionella pneumophila is an intracellular pathogen of freshwater amoeba and of alveolar macrophages in human hosts. After phagocytosis, L. pneumophila establishes a unique intracellular vacuolar niche that avoids entry into the lysosomal network. Critical for L. pneumophila intracellular growth is the Dot/Icm type IVB translocation system. Although over 80 substrates of the Dot/Icm apparatus have been identified, individual substrates are often genetically redundant, complicating their analysis. Deletion of critical Dot/Icm translocation system components causes a variety of defects during intracellular growth. Many of these effects on the host cell likely result from the actions of one or more Dot/Icm translocated substrates. Loss of single substrates never generates the profound effects observed in strains lacking translocation system components." @default.
- W2065183886 created "2016-06-24" @default.
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- W2065183886 date "2009-02-01" @default.
- W2065183886 modified "2023-09-29" @default.
- W2065183886 title "Legionella pneumophila Dot/Icm translocated substrates: a sum of parts" @default.
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- W2065183886 doi "https://doi.org/10.1016/j.mib.2008.12.004" @default.
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