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• W2065187795 abstract "Breviscapine lipid emulsions were prepared by a high speed dispersion-homogenization method with optimal formulation and technological method. The proportion of liposomes in breviscapine lipid emulsions, an important character for determining the behavior of drug in vivo belongs to which carriers, was less than 5%. Loading breviscapine into lipid emulsions did increase the breviscapine concentrations in plasma, retarded the clearance, and exhibited the properties of sustained-release concluded by pharmacokinetic parameters: after bolus administration, the elimination phase (t1/2(β) = 99.535) of lipid emulsions was 5.4-times longer than that of Injectio Breviscapine. The AUC0→∞ (14.453-times), k10 (0.047-times), Cls (0.147-times), and MRT0→∞ (17.766-times) values also confirmed this trend. The amount of drug in every tissue increased at different levels after intravenous administration of breviscapine lipid emulsions compared with Injectio Breviscapine. The relative exposure value of breviscapine lipid emulsions for plasma and lungs were 29.59 and 5.81, respectively, indicating that the exposure of breviscapine to plasma and lungs was significantly increased by entrapment in lipid emulsions. Other targeting evaluation indexes also proved the superiority of lipid emulsions carrier to deliver drug to the targeting region of vascular and lung diseases therapy." @default.
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• W2065187795 date "2010-10-28" @default.
• W2065187795 modified "2023-09-25" @default.
• W2065187795 title "Characterization, biodistribution and targeting evaluation of breviscapine lipid emulsions following intravenous injection in mice" @default.
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• W2065187795 doi "https://doi.org/10.3109/10717544.2010.528068" @default.
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