FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065191242> ?p ?o ?g. }

• W2065191242 endingPage "193" @default.
• W2065191242 startingPage "186" @default.
• W2065191242 abstract "Synthetic cystic fibrosis sputum medium (SCFM) is rich in amino acids and supports robust growth of Burkholderia cenocepacia, a member of the Burkholderia cepacia complex (Bcc). Previous work demonstrated that B. cenocepacia phenylacetic acid (PA) catabolic genes are up-regulated during growth in SCFM and are required for full virulence in a Caenorhabditis elegans host model. In this work, we investigated the role of phenylalanine, one of the aromatic amino acids present in SCFM, as an inducer of the PA catabolic pathway. Phenylalanine degradation intermediates were used as sole carbon sources for growth and gene reporter experiments. In addition to phenylalanine and PA, phenylethylamine, phenylpyruvate, and 2-phenylacetamide were usable as sole carbon sources by wild type B. cenocepacia K56-2, but not by a PA catabolism-defective mutant. EMSA analysis showed that the binding of PaaR, the negative regulator protein of B. cenocepacia PA catabolism, to PA regulatory DNA could only be relieved by phenylacetyl-Coenzyme A (PA-CoA), but not by any of the putative phenylalanine degradation intermediates. Taken together, our results show that in B. cenocepacia, phenylalanine is catabolized to PA and induces PA catabolism through PA activation to PA-CoA. Thus, PaaR shares the same inducer with PaaX, the regulator of PA catabolism in Escherichia coli, despite belonging to a different protein family." @default.
• W2065191242 created "2016-06-24" @default.
• W2065191242 creator A5030628335 @default.
• W2065191242 creator A5040410776 @default.
• W2065191242 creator A5041165679 @default.
• W2065191242 creator A5050763209 @default.
• W2065191242 creator A5060064795 @default.
• W2065191242 creator A5069468282 @default.
• W2065191242 creator A5070511956 @default.
• W2065191242 date "2011-09-01" @default.
• W2065191242 modified "2023-10-18" @default.
• W2065191242 title "Phenylalanine induces Burkholderia cenocepacia phenylacetic acid catabolism through degradation to phenylacetyl-CoA in synthetic cystic fibrosis sputum medium" @default.
• W2065191242 cites W1510205119 @default.
• W2065191242 cites W1529704948 @default.
• W2065191242 cites W1781531090 @default.
• W2065191242 cites W1906922449 @default.
• W2065191242 cites W1965591002 @default.
• W2065191242 cites W1969379388 @default.
• W2065191242 cites W1980751665 @default.
• W2065191242 cites W1986103520 @default.
• W2065191242 cites W1987139333 @default.
• W2065191242 cites W1989477075 @default.
• W2065191242 cites W1995063207 @default.
• W2065191242 cites W2026624424 @default.
• W2065191242 cites W2042823225 @default.
• W2065191242 cites W2065865092 @default.
• W2065191242 cites W2066438497 @default.
• W2065191242 cites W2072740820 @default.
• W2065191242 cites W2083121321 @default.
• W2065191242 cites W2084045864 @default.
• W2065191242 cites W2085844553 @default.
• W2065191242 cites W2097360396 @default.
• W2065191242 cites W2097944090 @default.
• W2065191242 cites W2099925167 @default.
• W2065191242 cites W2101266397 @default.
• W2065191242 cites W2101653602 @default.
• W2065191242 cites W2108716844 @default.
• W2065191242 cites W2109638827 @default.
• W2065191242 cites W2116747675 @default.
• W2065191242 cites W2122044132 @default.
• W2065191242 cites W2123060905 @default.
• W2065191242 cites W2125900529 @default.
• W2065191242 cites W2126006315 @default.
• W2065191242 cites W2126521605 @default.
• W2065191242 cites W2131145961 @default.
• W2065191242 cites W2132666490 @default.
• W2065191242 cites W2132732985 @default.
• W2065191242 cites W2136765539 @default.
• W2065191242 cites W2136984336 @default.
• W2065191242 cites W2145658355 @default.
• W2065191242 cites W2151906718 @default.
• W2065191242 cites W2159535681 @default.
• W2065191242 cites W2161406364 @default.
• W2065191242 cites W2165674132 @default.
• W2065191242 cites W2165955930 @default.
• W2065191242 cites W2171535756 @default.
• W2065191242 cites W4294216483 @default.
• W2065191242 doi "https://doi.org/10.1016/j.micpath.2011.04.002" @default.
• W2065191242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21511027" @default.
• W2065191242 hasPublicationYear "2011" @default.
• W2065191242 type Work @default.
• W2065191242 sameAs 2065191242 @default.
• W2065191242 citedByCount "13" @default.
• W2065191242 countsByYear W20651912422012 @default.
• W2065191242 countsByYear W20651912422013 @default.
• W2065191242 countsByYear W20651912422014 @default.
• W2065191242 countsByYear W20651912422016 @default.
• W2065191242 countsByYear W20651912422017 @default.
• W2065191242 countsByYear W20651912422018 @default.
• W2065191242 countsByYear W20651912422019 @default.
• W2065191242 countsByYear W20651912422022 @default.
• W2065191242 crossrefType "journal-article" @default.
• W2065191242 hasAuthorship W2065191242A5030628335 @default.
• W2065191242 hasAuthorship W2065191242A5040410776 @default.
• W2065191242 hasAuthorship W2065191242A5041165679 @default.
• W2065191242 hasAuthorship W2065191242A5050763209 @default.
• W2065191242 hasAuthorship W2065191242A5060064795 @default.
• W2065191242 hasAuthorship W2065191242A5069468282 @default.
• W2065191242 hasAuthorship W2065191242A5070511956 @default.
• W2065191242 hasConcept C104317684 @default.
• W2065191242 hasConcept C143065580 @default.
• W2065191242 hasConcept C2777431362 @default.
• W2065191242 hasConcept C2777756538 @default.
• W2065191242 hasConcept C2777979451 @default.
• W2065191242 hasConcept C2778990612 @default.
• W2065191242 hasConcept C2780855054 @default.
• W2065191242 hasConcept C515207424 @default.
• W2065191242 hasConcept C523546767 @default.
• W2065191242 hasConcept C54355233 @default.
• W2065191242 hasConcept C547475151 @default.
• W2065191242 hasConcept C55493867 @default.
• W2065191242 hasConcept C60987743 @default.
• W2065191242 hasConcept C62231903 @default.
• W2065191242 hasConcept C86803240 @default.
• W2065191242 hasConcept C89423630 @default.
• W2065191242 hasConcept C96942376 @default.
• W2065191242 hasConceptScore W2065191242C104317684 @default.
• W2065191242 hasConceptScore W2065191242C143065580 @default.

• next