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• W2065192907 abstract "A series of quinoline derivatives were synthesized and their immunosuppressive activity and cytotoxicity were evaluated with a T-cell functional assay and MTT method, respectively. Most of 5,7-dimethoxyquinolin-4-yl ortho-substituted benzoate derivatives (18, 22, 24, 28, 31 and 37) showed a quite stronger inhibitory activity compared to other analogs. Among the synthesized compounds, 5,7-dimethoxyquinolin-4-yl 2,6-dichlorobenzoate (22) and 5,7-dimethoxyquinolin-4-yl 4-methylbenzenesulfonate (40) exhibited a potent inhibitory activity without significant cytotoxicity at 10 μM concentration. The preliminary mechanism of the active compounds 22 and 40 was further clarified based on the fluorescence activated cell sorter (FACS) assay, and the compounds exerted immunosuppressive activity via inhibiting the T cell activation in a dose dependent manner." @default.
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• W2065192907 date "2009-08-01" @default.
• W2065192907 modified "2023-09-26" @default.
• W2065192907 title "Synthesis and evaluation of a novel series of quinoline derivatives with immunosuppressive activity" @default.
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• W2065192907 doi "https://doi.org/10.1016/j.bmc.2009.06.043" @default.
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